نتایج جستجو برای: mitochondrial complex i
تعداد نتایج: 1850523 فیلتر نتایج به سال:
Oxidative stress and mitochondrial dysfunction signify important biochemical events associated with the loss of dopaminergic neurons in Parkinson's disease (PD). Studies using in vitro and in vivo PD models or tissues from diseased patients have demonstrated a selective inhibition of mitochondrial NADH dehydrogenase (Complex I of the OXPHOS electron transport chain) that affects normal mitochon...
NADH-ubiquinone oxidoreductase (complex I) deficiency is amongst the most encountered defects of the mitochondrial oxidative phosphorylation (OXPHOS) system and is associated with a wide variety of clinical signs and symptoms. Mutations in complex I nuclear structural genes are the most common cause of isolated complex I enzyme deficiencies. The cell biological consequences of such mutations ar...
ژنوم میتوکندریایی شامل ?? ژن کد کنندهء پروتئین است. بسیاری از این ژن ها زنجیرهء انتقال را کد می کنند.ژن 5nd-mt یکی از 13 ژن کد کننده پروتئین است، که زنجیره انتقال الکترون را کد می کند. و جایگاه آن در(i complex)است. ژن 5nd-mt دستورالعمل برای ساختن یک پروتئین به نام nadh دهیدروژناز5 را فراهم می کند. این پروتئین بخشی از یک مجــتمع آنزیم های بزرگ شناخــــته شده با عنوان (i complex)است که در میتوک...
Mitochondrial complex I, the primary entry point for electrons into the mitochondrial respiratory chain, is both critical for aerobic respiration and a major source of reactive oxygen species. In the heart, chronic dysfunction driving cardiomyopathy is frequently associated with decreased complex I activity, from both genetic and environmental causes. To examine the functional relationship betw...
how to cite this article: khatami m, heidari mm, mansouri r, mousavi f. the polg polyglutamine tract variants in iranian patients with multiple sclerosis. iran j child neurol. 2015 winter; 9(1):37-41. abstract objective multiple sclerosis (ms) is a common disease of the central nervous system. the interaction between inflammatory and neurodegenerative processes typically results in irregular ne...
PURPOSE Many solid tumors exhibit abnormal aerobic metabolism characterized by increased glycolytic capacity and decreased cellular respiration. Recently, mutations in the nuclear encoded mitochondrial enzymes fumarate hydratase and succinate dehydrogenase have been identified in certain tumor types, thus demonstrating a direct link between mitochondrial energy metabolism and tumorigenesis. Alt...
Changes in mitochondrial function with age vary between different muscle types, and mechanisms underlying this variation remain poorly defined. We examined whether the rate of mitochondrial protein turnover contributes to this variation. Using heavy label proteomics, we measured mitochondrial protein turnover and abundance in slow-twitch soleus (SOL) and fast-twitch extensor digitorum longus (E...
Deficiencies in the activity of complex I (NADH: ubiquinone oxidoreductase) are an important cause of human mitochondrial disease. Complex I is composed of at least 46 structural subunits that are encoded in both nuclear and mitochondrial DNA. Enzyme deficiency can result from either impaired catalytic efficiency or an inability to assemble the holoenzyme complex; however, the assembly process ...
sepsis is a systemic inflammatory response to infection. sepsis, which can lead to severe sepsis, septic shock, and multiple organ dysfunction syndrome, is an important cause of mortality. pathogenesis is extremely complex. in recent years, cell hypoxia caused by mitochondrial dysfunction has become a hot research field. sepsis damages the structure and function of mitochondria,conversely, mito...
The effects of decylubiquinone, a ubiquinone analogue, on mitochondrial function and inhibition thresholds of the electron transport chain enzyme complexes in synaptosomes were investigated. Decylubiquinone increased complex I/III and complex II/III activities by 64 and 80%, respectively, and attenuated reductions in oxygen consumption at high concentrations of the complex III inhibitor myxothi...
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