After a 2-hr incubation with soluble immune response suppressor (SIRS), product of concanavalin A-activated murine T cells, macrophages release factor, M phi-derived factor (M phi-SF), which nonspecifically suppresses responses in vitro. The mechanism(s) action phi-SF and range cell types affected by have been investigated. suppressed antibody to background levels if added at culture initiation...

The coexistence of gastrointestinal tumors (GIST’s) with other several primary malignant neoplasms has been demonstrated. However, there is no study that reported simultaneous occurrence small bowel adenocarcinoma (SBA) and a GIST located in the stomach. Here, we report first case SBA synchronous gastric GIST. Surgical resection clinicopathological characterization were performed for masses ide...

The recent establishment of mammalian haploid embryonic stem cells (ESCs) provides new possibilities for genetic screening and for understanding genome evolution and function. However, the dynamics of mitosis in haploid ESCs is still unclear. Here, we report that the duration of mitosis in haploid ESCs, especially the metaphase, is significantly longer than that in diploid ESCs. Delaying mitosi...

Cell division is characterized by a sequence of events by which a cell gives rise to two daughter cells. Quantitative measurements of cell-cycle dynamics in single cells showed that despite variability in G1-, S-, and G2 phases, duration of mitosis is short and remarkably constant. Surprisingly, there is no correlation between cell-cycle length and mitotic duration, suggesting that mitosis is t...

Mitosis occurs efficiently, but when it is disturbed or delayed, p53-dependent cell death or senescence is often triggered after mitotic exit. To characterize this process, we conducted CRISPR-mediated loss-of-function screens using a cell-based assay in which mitosis is consistently disturbed by centrosome loss. We identified 53BP1 and USP28 as essential components acting upstream of p53, evok...

Mitonucleon-initiated dome formation involves structural changes occurring over a 20 to 24 hour period in monolayer cells induced by serum factor. The earliest observable change is the fusion of into syncytium which nuclei aggregate and become surrounded membrane that stains for endogenous biotin. Each these structures further fraction mitochondria arise following initiation formation. fuse aro...

During cell division, progression through mitosis is driven by a protein phosphorylation wave. This wave namely depends on an activation-inactivation cycle of cyclin B-dependent kinase (Cdk) 1 while activities of major protein phosphatases, like PP1 and PP2A, appear directly or indirectly repressed by Cdk1. However, how Cdk1 inactivation is coordinated with reactivation of major phosphatases at...

There are many claims that quantum mechanics plays a key role in the origin and/or operation of biological organisms. The mechanism of the meiosis, mitosis and gametes life cycle from the view-point of quantum for human has been represented. The quantum gates have been used to simulate these processes for the first time. The reason of several hundred sperms has been explained in the male too

Cells that cannot satisfy the spindle assembly checkpoint (SAC) are delayed in mitosis (D-mitosis), a fact that has useful clinical ramifications. However, this delay is seldom permanent, and in the presence of an active SAC most cells ultimately escape mitosis and enter the next G1 as tetraploid cells. This review defines and discusses the various factors that determine how long a cell remains...