Abstract A group is boundedly acyclic if its bounded cohomology with trivial real coefficients vanishes in all positive degrees. Amenable groups are acyclic, while the first nonamenable examples of compactly supported homeomorphisms $ {\mathbb {R}}^{n}$ (Matsumoto–Morita) and mitotic (Löh). We prove that binate (alias pseudo-mitotic) which provides a unifying approach to aforementioned results....

Abstract Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. Temozolomide (TMZ) part of standard care for patients with newly diagnosed GBM (ndGBM). Expression enzyme MGMT involved TMZ-induced DNA damage repair associated irresponsiveness some to TMZ. The addition lomustine (CCNU) TMZ demonstrated clinical benefit ndGBM. Tumor Treating Fields (TTFields) are electric f...

The relationship between cell morphology, proliferation, and contact inhibition was studied in normal and malignant human cells which varied in their sensitivity to contact inhibition. Their ability to proliferate was examined under conditions where the cells were constrained into different shapes by plating onto plastic surfaces coated with poly(2-hydroxyethyl methacrylate). Poly(2-hydroxyethy...

A method is described enabling the direct measurement of vincristine resistance in intact tissues in vivo by morphological study. Using the metaphase arresting properties of the drug, counts were made of escaping anaphase and telophase mitotic figures at a range of doses. The proportion of post-metaphase mitotic figures is called the post-metaphase index (PMI). In 95 primary intestinal tumours ...