(5R)-Cleistenolide and a few related analogues have been synthesized starting from d-glucose. The key steps of the synthesis included Z-selective Wittig olefination an intramolecular Mitsunobu reaction with inversion configuration at C-5 position. In vitro antiproliferative activity compounds was tested on panel eight human tumour cells against single normal cell line (MRC-5). majority showed s...

1 Molecular Cloning of Opioid Receptors by cDNA Library Screening Ying-Xian Pan ......................................................................................... 3 2 Expression of Opioid Receptors in Mammalian Cell Lines Ying-Xian Pan ....................................................................................... 17 3 Assessing Opioid Regulation of Adenylyl Cyclase Activity in I...

Four enantiomerically pure stereoisomers of rosaprostol (1), an antiulcer drug, were efficiently synthesized from the enantiomers of 2-(dimethoxyphosphoryl)-3-hexylcyclopentanone (3) as chiral substrates. The latter were obtained by resolution of racemic 3 with (+)-(R)-1-(1-naphthyl)ethylamine. The conversion of (+)-3 into rosaprostol stereoisomer (-)-1a was accomplished in four steps in 56% ov...

The development of new aminoglycoside analogues to reduce the emergence of bacterial resistance has become a topic of high interest. We describe here a rapid and facile access to orthogonally protected 2-deoxystreptamine (2-DOS), a meso-diaminocyclitol known to be a pivotal component of most active aminoglycosides. Our synthetic approach started from highly protected methyl alpha-D-glucopyranos...

We describe an efficient five-step, enantioselective synthesis of (R,R)- and (S,S)-lignin dimer models possessing a β-O-4 linkage, by using the Evans chiral aldol reaction as a key step. Mitsunobu inversion of the (R,R)- or (S,S)-isomers generates the corresponding (R,S)- and (S,R)-diastereomers. We further extend this approach to the enantioselective synthesis of a lignin trimer model. These l...