BACKGROUND In rats, esophagogastroduodenal anastomosis (EGDA) without concomitant chemical carcinogen treatment leads to gastroesophageal reflux disease, multilayered epithelium (MLE, a presumed precursor in intestinal metaplasia), columnar-lined esophagus, dysplasia, and esophageal adenocarcinoma. Previously we have shown that columnar-lined esophagus in EGDA rats resembled human Barrett's eso...

In this article, we have introduced a new probability distribution having three parameters using half Cauchy family of named extended exponential distribution. The statistical properties and characteristics the proposed like hazard rate function (HRF), cumulative function, density (PDF), (CDF), quantile skewness, kurtosis are provided. estimated Cramer-Von-Mises (CVM) least-square estimation (L...

Drosophila maleless (mle) is required for X chromosome dosage compensation and is essential for male viability. Maleless protein (MLE) is highly homologous to human RNA helicase A and the bovine counterpart of RNA helicase A, nuclear helicase II. In this report, we demonstrate that MLE protein, overexpressed and purified from Sf9 cells infected with recombinant baculovirus, possesses RNA/DNA he...

We study a class of quadratic stochastic programs where the distribution of random variables has unknown parameters. A traditional approach is to estimate the parameters using a maximum likelihood estimator (MLE) and to use this as input in the optimization problem. For the unconstrained case, we show that an estimator that shrinks the MLE towards an arbitrary vector yields a uniformly better r...

In this study, I investigate the necessary condition for the consistency of the maximum likelihood estimator (MLE) of spatial models with a spatial moving average process in the disturbance term. I show that the MLE of spatial autoregressive and spatial moving average parameters is generally inconsistent when heteroskedasticity is not considered in the estimation. I also show that the MLE of pa...

BACKGROUND The aim of the study was to estimate the effect of the accumulation of major life events (MLE) in childhood and adulthood, in both the private and working domains, on risk of type 2 diabetes mellitus (T2DM). Furthermore, we aimed to test the possible interaction between childhood and adult MLE and to investigate modification of these associations by educational attainment. METHODS ...

For the tree topology, previous studies show the maximum likelihood estimate (MLE) of a link/path takes a polynomial form with a degree that is one less than the number of descendants connected to the link/path. Since then, the main concern is focused on searching for methods to solve the high degree polynomial without using iterative approximation. An explicit estimator based on the Law of Lar...

A novel method based on MLE–OED is proposed for unsupervised image segmentation of multiple objects with fuzzy edges. It adjusts the parameters of a mixture of Gaussian distributions via minimizing a new loss function. The loss function consists of two terms: a local content fitting term, which optimizes the entropy distribution, and a global statistical fitting term, which maximizes the likeli...

The aim of this study was to evaluate the efficacy of two botulinum toxin A (BoNT-A) injection patterns with or without the medial lower eyelid (MLE) in treating benign essential blepharospasm (BEB) and influencing lacrimal drainage. Two different injection patterns of BoNT-A were randomly applied to 98 eyes of 49 BEB patients: MLE Group received a full injection pattern of 5 sites and non-MLE ...

We propose a two parameter Inverted Generalized Exponential (IGE) and a three parameter Generalized Inverted Generalized Exponential (GIGE) probability models as generalizations of the one-parameter Exponential distribution and some other distributions in the literature. We explore the statistical properties of the GIGE distribution and its parameters were estimated for both censored and uncens...