We performed a systematic screen of the set of approximately 5,000 viable Saccharomyces cerevisiae haploid gene deletion mutants and have identified 103 genes whose deletion causes sensitivity to the DNA-damaging agent methyl methanesulfonate (MMS). In total, 40 previously uncharacterized alkylation damage response genes were identified. Comparison with the set of genes known to be transcriptio...

Nearly 80 years have passed since Frederic Mohs began to develop the technique that now bears his name. During this period, the use of Mohs micrographic surgery (MMS) has spread and taken firm hold in some countries (especially the United States, where it originated), but has been more unevenly taken up in others, specifically in Europe. Few randomized clinical trials have compared treatment op...

The rate of incarcerated individuals in the United States continues to grow. At midyear 2005 the Nation’s prisons and jails incarcerated 2,186,230 persons. (Bureau of Justice 1). Prison systems are in need of a brief mental health-screening tool that rapidly and readily identifies mental illness and cooccurring substance abuse in inmates to improve the approach to mental health diagnosis and tr...

This article presents a novel concept, the minimal molecular surface (MMS), for the theoretical modeling of biomolecules. The MMS can be viewed as a result of the surface free energy minimization when an apolar molecule, such as protein, DNA or RNA is immersed in a polar solvent. Based on the theory of differential geometry, the MMS is created via the mean curvature minimization of molecular hy...

The pathogenic fungus Candida albicans switches from yeast growth to filamentous growth in response to genotoxic stresses, in which phosphoregulation of the checkpoint kinase Rad53 plays a crucial role. Here we report that the Pph3/Psy2 phosphatase complex, known to be involved in Rad53 dephosphorylation, is required for cellular responses to the DNA-damaging agent methyl methanesulfonate (MMS)...

We introduce a novel concept, the minimal molecular surface (MMS), as a new paradigm for the theoretical modeling of biomolecule-solvent interfaces. When a less polar macromolecule is immersed in a polar environment, the surface free energy minimization occurs naturally to stabilizes the system, and leads to an MMS separating the macromolecule from the solvent. For a given set of atomic constra...

Sorting is a primitive operation that is a building block for countless algorithms. As such, it is important to design sorting algorithms that approach peak performance on a range of hardware architectures. Graphics Processing Units (GPUs) are particularly attractive architectures as they provides massive parallelism and computing power. However, the intricacies of their compute and memory hier...

15 1 Even though Jansen's NetLingo Internet Dictionary postulates the hyphenised spelling of the word email, i.e. " e-mail " , arguing that email is short for " electronic mail " , it will be spelt without a hyphen in this volume for the simple reason that the language of CMC tends to be reduced, so hyphens do not ¿ t in the concept of shortenings. Also, it can be recognised that people tend to...

Fair division is a fundamental problem in various multi-agent settings, where the goal to divide set of resources among agents fair manner. We study case m indivisible items need be divided n with additive valuations using popular fairness notion maximin share (MMS). An MMS allocation provides each agent bundle worth at least her share. While it known that such an not exist [1], [2], series rem...

Intertumoral molecular heterogeneity in glioblastoma identifies four major subtypes based on expression of molecular markers. Among them, the two clinically interrelated subtypes, proneural and mesenchymal, are the most aggressive with proneural liable for conversion to mesenchymal upon therapy. Using two patient-derived novel primary cell culture models (MTA10 and KW10), we developed a minimal...