Using resting state functional magnetic resonance imaging (MRI), we aim to understand the neurologic basis of improved function in children with hemiplegic cerebral palsy treated with constraint-induced movement therapy. Eleven children including 4 untreated comparison subjects diagnosed with hemiplegic cerebral palsy were recruited from 3 clinical centers. MRI and clinical data were gathered a...

As reported in a recent review, the most promising interventions for restoring function of the arm seem to be high-repetition doses of task-oriented training, such as constraint-induced movement therapy [3]. However, constraint-induced movement therapy requires considerable clinical staff input and a long treatment time, which makes clinical introduction impractical [4]. In fact, the reality of...

BACKGROUND AND PURPOSE Studies on adult stroke patients have demonstrated functional changes in cortical excitability, metabolic rate, or blood flow after motor therapy, measures that can fluctuate rapidly over time. This study evaluated whether evidence could also be found for structural brain changes during an efficacious rehabilitation program. METHODS Chronic stroke patients were randomly...

Constraint-induced movement therapy (CIMT) has gained considerable popularity as a treatment technique for upper extremity rehabilitation among patients with mild-to-moderate stroke. While substantial evidence has emerged to support its applicability, issues remain unanswered regarding the best and most practical approach. Following the establishment of what can be called the "signature" CIMT a...