Most drugs cannot be given orally because of significant degradation in the GIT or first pass metabolism in the liver. Nasal route for the delivery of some drugs offers an alternative in the pharmaceutical industry. The present review deals with the utility of the nasal route for the delivery of drugs to the brain as a microemulsion system in the treatment of a number of ailments like migraine,...

We have prepared a viscous bicontinuous microemulsion consisting of water / [20 wt% POE-GIS + 30 wt% PEPTME + 47.5 wt% POE/POP-PDMS + 2.5 wt% OA)] / DMPS system. A pseudoternary phase diagram was constructed for the mixture, and the bicontinuous microemulsion phase was characterized by means of rheometry and freeze-fracture transmission electron microscopy (FF-TEM).

CdS nanocrystals were prepared in water-in-oil microemulsions. The nanocrystal properties, absorption and luminescence spectra and size distributions, were monitored at different times after mixing the microemulsions of the two precursors to obtain information on their growth mechanism. In particular, CdS nanocrystals were prepared using water-in-heptane or water-in-nonane microemulsions. The r...

The removal of model pollutants bromocresol green (BG) and phenol from water is demonstrated via two liquid-liquid extraction methods. Both methods exploit selective interactions established by the pollutant molecule with a surfactant, oil, or alcohol, and are variants of the more general Winsor systems where the phases are in contact along an extremely large interfacial area. In the first meth...

Nasal application of benzodiazepines might be an alternative to intravenous administration in acute clinical situations such as seizures emergencies. However, irritation and pain as well as symptoms like teary eyes, dizziness, discomfort, nasal drainage and bad taste usually accompany subject received midazolam and diazepam via the nasal route. The purpose of this study was to evaluate the use ...

In this study, tretinoin microemulsion has been formulated based on phase diagram studies by changing the amounts and proportions of inactive ingredients, such as surfactants, co-surfactants and oils. The effects of these variables have been determined on microemulsion formation, particle size of the dispersed phase and release profile of tretinoin from microemulsion through dialysis membrane. ...

In this study, tretinoin microemulsion has been formulated based on phase diagram studies by changing the amounts and proportions of inactive ingredients, such as surfactants, co-surfactants and oils. The effects of these variables have been determined on microemulsion formation, particle size of the dispersed phase and release profile of tretinoin from microemulsion through dialysis membrane. ...

polydimethylsiloxane (pdms) has been synthesized by ring-opening polymerization of octamethylcyclotetrasiloxane (d4) in microemulsion with acidic catalyst. the structure and properties of microemulsion were characterized by transmission electron microscopy (tem), fourier transform infrared spectroscopy (ft-ir), photo correlation spectroscopy (pcs). the effect of the variation in ph value, amoun...

Microemulsions improve the transdermal delivery of several drugs over conventional topical preparations such as emulsions and gels: enhanced drug solubilization, increased skin flux, decreased diffusion coefficient. Microemulsion-based systems find significant improvement in antifungals. We believe that drug-loaded microemulsion will show better antifungal activity by penetration into fungal ce...

Microemulsions are psuedohomogeneous mixtures which may show special performance towards reaction equilibria, nanoscale synthesis and reaction dynamics. Rate of reaction are most often accelerated in microemulsion media compared to that in water. This study is an effort to review some important reaction kinetics measured in reverse micro emulsion media. In the same time some pioneering research...