BACKGROUND AND PURPOSE Pretreatment infarct volume appears to predict clinical outcome after intra-arterial therapy. To confirm the importance of infarct size in patients undergoing intra-arterial therapy, we sought to characterize the relationship between final infarct volume (FIV) and long-term functional outcome in a prospective cohort of endovascularly treated patients. METHODS From our p...

BACKGROUND AND PURPOSE Uric acid (UA) is a neuroprotective antioxidant that improves the benefits of alteplase in experimental ischemia. However, it is unknown whether endogenous UA also influences the response to thrombolysis in patients with stroke. METHODS A total of 317 consecutive patients treated with thrombolysis were included in a prospective stroke registry. Demographics, laboratory ...

Transplantation of autologous bone marrow mononuclear cells (BMMCs) has been proven safe in animal and human studies. However, there are very few studies in stroke patients. In this study, intra-arterial autologous BMMCs were infused in patients with moderate to severe acute middle cerebral artery infarcts. The subjects of this study included 20 patients with early or late spontaneous recanali...

BACKGROUND AND PURPOSE For selected stroke patients, intra-arterial thrombolysis (IAT) has been shown to be an effective treatment option. However, knowledge of safety and efficacy of IAT in patients with acute stroke as a complication of arterial catheter interventions is limited. METHODS We analyzed clinical radiological findings and functional outcomes in consecutive patients 3 months afte...

BACKGROUND AND PURPOSE Although intracerebral hemorrhages are frequent in patients with cerebral venous thrombosis, and lead to worse outcome, predictors of outcome in cerebral venous thrombosis patients with intracerebral hemorrhages have never been evaluated in adequately powered studies. METHODS This study was conducted as a part of the International Study on Cerebral Vein and Dural Sinus ...

BACKGROUND Factors affecting the quality of life (QOL) may be different between young and old stroke patients. However, these issues have not yet been properly investigated. METHODS We identified 170 young-onset stroke patients (onset between 15 and 45 years of age) who were admitted to the Asan Medical Center. Three hundred and forty follow-up period matched, old-onset stroke patients (onset...

BACKGROUND AND PURPOSE The purpose of this study was to assess the frequency, severity, and predictors of neurological deficits after adjuvant embolization for cerebral arteriovenous malformations. METHODS From 1997 to 2006, 202 of 275 patients with arteriovenous malformation received embolization before microsurgery (n=176) or radiosurgery (n=26). Patients were examined before and after endo...

The relationship between modified Rankin Scale (mRS) and optimal timing of carotid revascularization in patients with prior stroke is unclear. Therefore, we compared outcomes transfemoral artery stenting (TFCAS), transcarotid (TCAR), endarterectomy (CEA) after stroke, stratified by accounting for preoperative mRS time-to-intervention. We identified all who underwent TFCAS, TCAR, CEA a recent th...