Elastases in cystic fibrosis (CF) pulmonary fluids damage lung tissue and perpetuate cycles of infection, inflammation and injury. Elastases from three different sources may be present in CF airways: neutrophils, macrophages and Pseudomonas. We measured how well the cephalosporin-based antielastase L-658,758 blocks the activity of human neutrophil elastase (NE), human proteinase-3, human macrop...

We have applied the sol-gel process to generate optical microstructures in glass using in-house developed sol-gel materials. The synthesis of our sol-gel glass materials is based on the formation of particles of controlled size from organo-metallic compounds. The overall shrinkage during annealing of the gel material is negligible and does not imply crack formation. Silica, titania and binar y ...

Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft copolymer abbreviated SOL) were produced using hot melt extrusion. Since ITZ possesses a water solubility of less than 1ng/mL, the aim of this work was to enhance the aqueous solubility of ITZ, and thereby improve its bioavailability. The three for...

Hybrid materials, i.e., the organically modified silicates (ORMOSIL) based on zincphthalocyanine (ZnPc) and silica glass matrix were synthesized by sol-gel method using protic solvents (methanol, ethanol, isopropanol, butanol) aprotic solvent (N,N-dimethylformamide; DMF). The effect of an alkaline environment with NaOH addition (a single-stage process) acid–alkaline CH3COOH-NH4OH HCl-NaOH two-s...

It has been shown that cat soleus (SOL) forces remain nearly constant despite increases in electromyography (EMG) activity for increasing speeds of locomotion, while medial gastrocnemius (MG) forces and EMG activity increase in parallel. Furthermore, during jumping, average cat SOL forces decrease, while average EMG activity increases dramatically compared with walking conditions. Finally, duri...

The objective of this research was to investigate how the photocatalytic activity pure TiO2 can be improved by SnO2 modification. Different molar ratios tin titanium were prepared. correlation between concentration and structural properties investigated explain mechanism efficiency optimize synthesis conditions obtain enhanced SnO2-modified photocatalysts under UV-irradiation. prepared a low-te...

................................................................................... viii CHAPTER 1. INTRODUCYION ........................................................... 1 1.1 Motivation ................................................................................. 1 1.2 Outline ..................................................................................... 2 CHAPTER 2. SOL-GEL PHOT...

Bacterial adhesion to surfaces is the first step in biofilm formation, which leads development of conditions that may compromise health status patients. Surface modification has been proposed reduce bacterial biomaterials. The objective this work was assess and compare Streptococcus mutans surface biomimetically-modified stainless steel using different topographies. Stainless plates were modifi...

In this paper,the preparation of nano silica sol was used TEOS hydrolysis. Silica sol was used to compound the SiO2 sol / polyacrylate with acrylate monomer emulsion polymerization, the effect of sol amount and feeding methods of polyacrylate stability and other property of SiO2 / polyacrylate were studied.

TiO2 nanoparticles, as a photocatalyst for oxidation of dimethyl methylphosphonate (DMMP) as an organophosphorus simulant of chemical warfare agent, were prepared by using sol-gel method. The prepared nanoparticles were then modified with transition metals in order to decrease the electron-hole recombination and increase the photocatalytic activity. Transition metal ions including Pt...