The flavonoid silymarin and one its structural components, silibinin, have been well characterized as hepato-protective substances. However, little is known about the biochemical mechanisms of action of these substances. This review deals with recent investigations to elucidate the molecular action of the flavonoid. Three levels of action have been proposed for silymarin in experimental animals...

Brain dopamine receptors have been preferred targets for numerous pharmacological compounds developed for the treatment of various neuropsychiatric disorders. Recent discovery that D2 dopamine receptors, in addition to cAMP pathways, can engage also in Akt/GSK3 signaling cascade provided a new framework to understand intracellular signaling mechanisms involved in dopamine-related behaviors and ...

Despite the huge effort to contain infection, novel SARS-CoV-2 coronavirus has rapidly become pandemic, mainly due its extremely high human-to-human transmission capability, and a surprisingly viral charge of symptom-less people. While seek for vaccine is still ongoing, promising results have been obtained with antiviral compounds. In particular, lactoferrin regarded beneficial effects both in ...