Methoxychlor, a currently used pesticide, is a proestrogen exhibiting estrogenic activity in mammals in vivo. Methoxychlor undergoes oxidative metabolism by cytochromes P450, yielding 1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane (mono-OH-M) and 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane (bis-OH-M) as main metabolites. Since humans may be exposed to these estrogenic metaboli...

introduction: the different factors that affect the camera uniformity of single photon emission computed tomography (spect) technique have been analyzed including peak shift (%) and window width of energy. the effect of peak shift and window width on spect image uniformity has been investigated using a point source to perform intrinsic flood images. methods:the relation between calculated integ...

Recombinant human granulocyte colony stimulating factor (rhG-CSF) and its PEGylated product "mono-PEG20-GCSF" have already been widely used for treatment of all kinds of neutropenia. However, the high required dosage of mono-PEG20-GCSF made it relatively expensive in clinical use. We postulated that an N-terminal site-specific PEGylated rhG-CSF with higher PEG Mw (PEG30 kDa) might be able to ac...

land surface temperature (lst) is a significant parameter for many applications. many studies have proposedvarious algorithms, such as the split-window method, for retrieving surface temperatures from two spectrallyadjacent thermal infrared bands of satellite data. each algorithm is developed for a limited study area andapplication. in this paper, as part of developing an optimal split-window m...