We studied the effects of vitamin D3 compounds on the replication of human immunodeficiency virus type 1 (HIV-1) in the monoblastoid cell line U937 and in primary monocyte-derived macrophage cultures to understand how modulators of monocyte/macrophage effector function might affect the pathogenesis of HIV-1 infection. U937 cell cultures exposed to 1, alpha 25-dihydroxyvitamin D3 prior to HIV-1 ...

Abstract The nuclear receptor related 1 protein (Nurr1) is a member of the orphan hormone family whose expression has been associated with several inflammatory diseases. Macrophages are key regulators processes, yet information about role Nurr1 in human macrophages limited. In present study we examined and activity steady state activated monocyte-derived macrophages. Pro- anti-inflammatory were...