Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is an autosomal dominant, fatal developmental disorder of the lungs, with a mortality rate of about 100%. ACD/MPV is caused by mutations in FOXF1. Herein, we describe a newborn boy with ACD/MPV carrying a novel pathogenic variant of FOXF1. The patient developed respiratory distress and severe pulmonary hypertension on t...

This paper presents a conceptual framework for verifying product properties at module level, Module Property Verification (MPV). MPV is an approach to decrease overall lead-times and increase the quality of modularised products. Pre-studies indicate that companies tend to have the majority of property verifications at product level, Product Property Verification (PPV), which may results in incr...

Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a rare, fatal developmental lung disorder of neonates and infants, associated with severe persistent pulmonary hypertension unresponsive to treatment. We reported the case of a term newborn with delayed presentation of ACD/MPV and a novel mutation of FOXF1 gene that received supportive cardiopulmonary treatments, inh...

After stenosis of arteriovenous vascular access in hemodialysis patients, platelets play a crucial role in subsequent thrombus formation, leading to access failure. In a previous study, the mean platelet volume (MPV)/platelet count ratio, but not MPV alone, was shown to be an independent predictor of 4-year mortality after myocardial infarction. However, little is known about the potential infl...

permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. When platelets are activated, they increase in size and change from a quiescent disc to a swollen sphere. Large platelets are more reactive and likely aggregate more than small ones. 1 Mean platelet volume (MPV), an indicator of platelet size and activation , has ...

INTRODUCTION Platelet activation plays an important role in the pathophysiology of non-ST elevation acute coronary syndromes (ACS). Mean platelet volume (MPV), an indicator of platelet reactivity, was previously associated with an increased risk of acute coronary events. OBJECTIVE To investigate the MPV variability in young patients presenting with NSTEMI, as compared to young patients with c...

AIM To investigate association of mean platelet volume (MPV) and glycemic control markers, and whether MPV could be used as a predictor of deterioration of glucoregulation in Diabetes mellitus type 2 (DMT2) patients. METHODS The cross-sectional study included 106 DMT2 patients, treated at the Primary Health Care Centre in Zenica, distributed into groups according to glycated haemoglobin (HbA1...

background mean platelet volume (mpv) is generally accepted as a new marker of cardiovascular disease risk in several studies. objectives this study aimed to determine the association of mpv with androgen hormones and insulin resistance (ir) in nonobese patients with polycystic ovary syndrome (pcos). patients and methods a total of 136 patients with newly diagnosed reproductive-age pcos (regard...

Background Larger platelets are more active and mean platelet volume (MPV) is an indicator of platelet activation and an independent risk factor of cardiovascular diseases. While MPV is reported to be higher in diabetic patients, the relationship between MPV and glycemic parameters in general population remains inconclusive. Methods In this cross-sectional study, we studied relationship betwe...

Dear the Editor, We have been interested in the mean platelet volume (MPV) measured by automated cell analyzer and were studying on the correlation between MPVs and various diseases (Lee and Kim 2010a, 2010b, 2010c). In the meanwhile, we read the article by Acikgoz and colleagues on the increased MPV in Behcet’s disease (BD) with thrombotic tendency (Acikgoz et al. 2010). In this article, the a...