BACKGROUND Statins have anti-inflammatory and immunomodulatory properties in addition to lipid-lowering effects. OBJECTIVES To report the 12-month extension of a phase II trial evaluating the efficacy, safety and tolerability of atorvastatin 40 mg/d added to interferon beta-1b (IFNB-1b) in relapsing-remitting multiple sclerosis (RRMS). METHODS In the randomized, multicenter, parallel-group,...

We report evidence for an Fe Kα fluorescence line feature and disk reflection in the Very High, High, and Low State X-ray spectra of the galactic microquasar XTE J1748−288 during its June 1998 outburst. Spectral analyses are made on data gathered throughout the outburst by the Rossi X-ray Timing Explorer Proportional Counter Array. Gaussian line, relativistic disk emission line, and ionized dis...

BACKGROUND Corpus callosum (CC) is a common target for multiple sclerosis (MS) pathology. We investigated the influence of CC damage on physical disability and cognitive dysfunction using a multimodal approach. METHODS Twenty-one relapsing-remitting MS patients and 13 healthy controls underwent structural MRI and diffusion tensor of the CC (fractional anisotropy; mean diffusivity, MD; radial ...

BACKGROUND Multiple sclerosis (MS) is characterized by demyelinating and degenerative processes within the central nervous system. Unlike conventional MRI,new advanced imaging techniques improve pathological specificity and better highlight the relationship between anatomical damage and clinical impairment. OBJECTIVE To investigate the relationship between clinical disability and both grey (G...

BACKGROUND We have recently completed an evaluation of the safety and feasibility of intravenous delivery of autologous bone marrow in patients with progressive multiple sclerosis (MS). The possibility of repair was suggested by improvement in the neurophysiological secondary outcome measure seen in all participants. The current study will examine the efficacy of intravenous delivery of autolog...

While NASA’s current next-generation launch vehicle research has largely focused on advanced allrocket single-stage-to-orbit vehicles (i.e. the X-33 and it’s RLV operational follow-on), some attention is being given to advanced propulsion concepts suitable for “next-generation-and-a-half” vehicles. Rocketbased combined-cycle (RBCC) engines combining rocket and airbreathing elements are one cand...

..̂IJ Previous papers described the Phase IA tests of the Rocketdyne configuration of the Space Shuttle Main Engine (SSME) High Pressure Fuel Turbopump (HPFTP) turbine with rough coated flight engine rotor blades and with polished coated rotor blades at Marshall Space Flight Center (MSFC) . The testing involved using scaled performance parameters and model measurements to determine the performan...

This paper presents a Quality Function Deployment (QFD) analysis of the h a l down-selected aqueous cleaners to be used on the Redesigned Solid Rocket Motor (RSRM) program. The new cleaner will replace solvent vapor degreasing. The RSRM Ozone Depleting Compound Elimination program is discontinuing the methyl chloroform vapor degreasing process and replacing it with a spray-in-air aqueous cleani...

THERE has been significant work recently in the development of iodine-fed Hall thrusters for in-space propulsion applications.1 The use of iodine as a propellant provides many advantages over present xenon-gas-fed Hall thruster systems. Iodine is a solid at ambient temperature (no pressurization required) and has no special handling requirements, making it safe for secondary flight opportunitie...

Lunar samples are not readily available for In-Situ Resource Utilization (ISRU) studies, necessary for preparations for a return to the Moon with landers, robots, and astronauts. Lunar soil simulants have been produced as substitutes for the real thing; BUT how good are they? JSC-1 and 1A were produced only to approximate the geotechnical properties of lunar soil, with its natural glassy compon...