background although it is life-saving, blood transfusion therapy has resulted in risk for transfusion-transmitted infections (ttis) in the majority of sickle cell anemia being patients. objectives the current study aimed to determine the prevalence of hbv, hcv and different genotypes of hcv among sickle cell anemia (sca) patients in ahvaz city, south-western iran. materials and methods a cross-...

Background: HCV infection is very common in multi-transfused β-thalassemia patients who need regular blood transfusions. Aim: The study was conducted to determine the epidemiology of West Bengal, India. Methods: Over a span six years, samples were collected from sero-reactive and processed for viral RNA isolation followed by nested RT-PCR qualitative viremia detection. genotype determined ampli...

INTRODUCTION Transfusions of one or more packed red blood cells is a widely strategy used in cardiac surgery, even after several evidences of increased morbidity and mortality. The world's blood shortage is also already evident. OBJECTIVE To assess whether the risk of mortality is dose-dependent on the number of packed red blood cells transfused after coronary artery bypass graft. METHODS B...

Introduction: Transfusions of one or more packed red blood cells is a widely strategy used in cardiac surgery, even after several evidences of increased morbidity and mortality. The world’s blood shortage is also already evident. Objective: To assess whether the risk of mortality is dose-dependent on the number of packed red blood cells transfused after coronary artery bypass graft. Methods: Be...

INTRODUCTION Repeated blood transfusions can result in the production of alloantibodies against one or more red cell antigens, which complicates subsequent transfusions. Aims: The study was done to find incidence of various red cell alloantibodies; to determine the type of alloantibody; to identify the factors such as frequency of transfusion, splenectomy status, donor ethnicity and gender and ...

Background: b-Thalassemia major is a serious medical problem.Growth retardation is commonly seen in poly-transfused b-thalassemia patients. The exact mechanism of short stature in childrenwith thalassemia major is not well understood, however, it isbelieved to be multi-factorial.Objective: To study the growth state and its relationship to growthhormone (GH) deficiency in b-thalassemia patients....

Red blood cell (RBC) transfusion is a key treatment of patients with sickle cell disease (SCD) but remains complicated by RBC immunization. In the present study, we evaluated the effects of antigen matching for Rh D, C, and E, and K and transfusion from African American donors in 182 patients with SCD. Overall, 71 (58%) chronic and 9 (15%) episodically transfused patients were alloimmunized. Fi...

Patients with severe aplastic anemia were conditioned with cyclophosphamide (200 mg/kg) and given marrow grafts from HLA-identical family members. Among 233 patients transplanted, 225 survived greater than or equal to 14 days and could be evaluated for engraftment. Forty-four of the 225 rejected their graft; 33 of these died and 11 survive. One hundred eighty-one patients had sustained engraftm...