Dimethyl sulfoxide (DMSO) is widely used as a solvent in organic synthesis and pharmacology because of its low cost, stability, non-toxicity. Multicomponent reactions are powerful synthetic tool for the rapid efficient construction complicated molecular frameworks. In this communication, multicomponent transformation salicylaldehyde, malononitrile dimer, dimethyl malonate DMSO at room temperatu...

A very short and efficient synthesis of the important drug candidate telaprevir, featuring a biocatalytic desymmetrization and two multicomponent reactions as the key steps, is presented. The classical issue of lack of stereoselectivity in Ugi- and Passerini-type reactions is circumvented. The atom economic and convergent nature of the synthetic strategy require only very limited use of protect...

The synthesis of six cyclic depsipeptoids inspired by the natural depsipeptide sansalvamide A is described. An efficient and fast synthetic strategy was developed using a combination of consecutive isocyanide-based multicomponent reactions (Ugi and Passerini reactions). This methodology can be used to access a variety of cyclic oligodepsipeptoids.

Interest in multicomponent reactions (MCRs) has surged during the past two decades as interest in the efficient synthesis of small molecule libraries has gained prominence. MCRs fill an important niche in library synthesis by providing direct access to library compounds and by serving as starting points for Diversity-Oriented Synthesis (DOS). Recent advances in the area of MCR chemistry have in...

a facile co-precipitation method for the synthesis of well-dispersed ndfeo3 nanocrystals is developed in the presence of octanoic acid as surfactant. co-precipitation can produce fine, high-purity, stoichiometric particles of single and multicomponent metal oxides. the product is characterized by fourier transform infrared spectroscopy (ft-ir), x-ray diffraction (xrd), scanning electron microsc...