The advances in reproductive technologies have changed the demographics of multifetal pregnancies. In the first trimester, ultrasound allows to diagnose the number of multiples, chorionicity and amnionicity, the presence or absence of nuchal translucency, early growth discordance, severe malformations and the origin of activities and contacts between multiples. In the second and third trimester...

Cigarette smoking adversely affects every organ system. Paradoxically, smoking during pregnancy has been associated with a reduced risk of preeclampsia. We reviewed previous epidemiologic and clinical studies on the association between smoking and preeclampsia from 1959 to March, 2006. A total of 48 epidemiologic studies were identified. Overall, smoking during pregnancy reduces the risk of pre...

Objectives: In multifetal pregnancies abnormalities within the umbilical cord occur much more frequently than in single pregnancy. This may be related to the presence of intra-uterine congestion, which is observed in the case of simultaneous development of a greater number of fetuses. These abnormalities may be responsible, at least in some cases, for high rate of perinatal morbidity and mortal...

OBJECTIVE As the first laboratory to offer massively parallel sequencing-based noninvasive prenatal testing (NIPT) for fetal aneuploidies, Sequenom Laboratories has been able to collect the largest clinical population experience data to date, including >100,000 clinical samples from all 50 U.S. states and 13 other countries. The objective of this study is to give a robust clinical picture of th...

BACKGROUND Infection in pregnancy may be involved in the aetiology of pre-eclampsia. However, a clear association between acute maternal infection and pre-eclampsia has not been established. We assessed whether acute urinary tract infection, respiratory tract infection, and antibiotic drug prescriptions in pregnancy (a likely proxy for maternal infection) are associated with an increased risk o...

Background: The first trimester begins on the day of last menstrual period (LMP) and lasts until end 12 weeks gestation. Transvaginal ultrasound is modality choice for establishing presence an intrauterine pregnancy in trimester. focus our study routine early ultrasound. purpose this was to diagnose various conditions at stage by using ultrasound.Methods: We conducted retrospective data analysi...