Aim . To study the association of nucleotide polymorphisms in platelet receptor and cytochrome P450 genes with development resistance to antiplatelet drugs CHD patients. Material Methods The included 243 patients diagnosed after coronary artery bypass surgery (CABG), including 140 acetylsalicylic acid (ASA) treatment group 103 dual therapy (DAT) group. All were tested for aggregation using an o...

Most cases of BCR-ABL1-negative myeloproliferative neoplasms (MPNs), essential thrombocythemia, polycythemia vera and primary myelofibrosis are associated with JAK2 (V617F) mutations. The outcomes of these cases are critically influenced by the transition from JAK2 (V617F) heterozygosity to homozygosity. Therefore, a technique providing an unbiased assessment of the critical allele burden, 50% ...

Potato virus Y (PVY) and Phytophthora infestans (Mont.) de Bary that causes potato late blight (LB), pose serious constraints to cultivated potatoes due significant yield reduction, phenotyping for resistance remains challenging. Breeding operations vegetatively propagated crops can lead genotype mislabeling that, in turn, reduces genetic gains. Low-density low-cost molecular marker assessment ...

Multiple myeloma (MM) is a hematological malignancy with a poor prognosis, characterized by clonal proliferation of plasma cells in the bone marrow (BM). Relapse due to undetected minimal residual disease (MRD) is the leading cause of death among patients with MM. This review summarizes the methods and prognostic value of MRD assessment in BM and autografts from MM patients who underwent autolo...

INTRODUCTION The T to C transition at nucleotide 1565 of the human glycoprotein IIIa (ITGB3) gene represents a genetic polymorphism (PlA1/A2) that can influence both platelet activation and aggregation and that has been associated with many types of disease. Here, we present a newly designed multiplex tetra-primer amplification refractory mutation system - polymerase chain reaction (T-ARMS-PCR)...