Ionizing radiation is the most established risk factor for meningioma formation. Our aim was to evaluate the main effect of selected candidate genes on the development of meningioma and their possible interaction with ionizing radiation in the causation of this tumor. The total study population included 440 cases and controls: 150 meningioma patients who were irradiated for tinea capitis in chi...

The Ki-67 proliferative index is a widely accepted assay for cycling cells within tumor specimens of multiple histological subtypes. While it is not a substitute for the World Health Organization (WHO) grading, the Ki-67 proliferative index is thought to correlate with the biological activity of selected tumors. In the case of intracranial meningiomas, many lesions may be resected multiple time...

Cells resembling bone marrow mesenchymal stem cells (BM-MSCs) have been isolated from glioma specimens; however, little is known about the existence of mesenchymal stem-like cells (MSLCs) in meningioma. Here, we hypothesized that cells similar to BM-MSCs exist in meningioma specimens and sought to investigate whether these putative meningioma stroma MSLCs (MS-MSLCs) could be isolated. To this e...

Meningiomas are relatively common primary adult brain tumors. They slow-growing, highly vascular, and graded according to histology, phenotypic genotypic features. We present a case of 66-year-old male with history tongue squamous cell carcinoma, which presented multiple risk factors for cardiovascular thromboembolic events. A lesion was initially detected on computed tomography (CT) scan later...

Meningioma merupakan jenis neoplasma intrakranial ekstraaksial yang paling umum dijumpai. Seiring dengan berkembangnya ilmu genomik, beberapa studi mulai meneliti asosiasi kejadian meningioma keberadaan single-nucleotide polymorphisms (SNPs). Penelitian ini bertujuan untuk melihat hubungan antara SNP risiko terjadinya meningioma. Penelusuran literatur dilakukan pada berbagai database kemudian d...

Clear-cell meningioma is a rare subtype of meningioma which occurs at a younger age and has a higher recurrence rate than other subtypes. We report two cases of clear-cell meningioma, one in the thoracolumbar spinal canal and the other in the cerebellopontine angle. Though the CT and MR imaging findings were not different from those of ordinary meningioma, after surgical removal the condition r...

introduction: meningioma is a benign and slowly-growing tumor that is responsible for 20% of brain neoplasms. it can be accompanied by some genetic disorders such as neurofibromatosis type 2 and is more common among women. as a space occupying lesion, it produces a wide range of signs and symptoms by compressing the adjacent and underlying tissues in the brain. trauma and viruses are possible e...

OBJECT The 2-fold higher incidence of meningioma in women compared with men has long suggested a role for hormonally mediated risk factors, but specific mechanisms remain elusive. METHODS The study included data obtained in 1127 women 29-79 years of age with intracranial meningioma diagnosed among residents of Connecticut, Massachusetts, North Carolina, the San Francisco Bay Area, and 8 Texas...

Rhabdoid meningioma is a rare aggressive variant of meningioma, regarded as WHO Grade III type. Histologically and cytologically, it is distinctive type having abundant eosinophilic cytoplasm, cytoplasmic inclusion with eccentrically placed vesicular nuclei and prominent nucleoli. High recurrence rate and poor outcome are important features. Here, we are presenting a rare case of rhabdoid menin...