multiple sclerosis (ms) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. ionic conductances regulate t cell activation as well as neuronal function and thus have been found to play a crucial role in ms pathogenesis. since present therapeutical approaches are only parti...

multiple sclerosis is an autoimmune cns-disease characterized by inflammatory neurodegenerative events occurring with de- and remyelination. recent evidence show that demyelinated neurons are less excitable than myelinated ones while at early stages of remyelination these neurons seem to be hyperexcitable. the latter is a transitory condition that, very likely, leads to impaired neuronal networ...

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It is well established that expertise modulates evoked brain activity in response to specific stimuli. Recently, researchers have begun to investigate how expertise influences the resting brain. Among these studies, most focused on the connectivity features within/across regions, i.e., connectivity patterns/strength. However, little concern has been given to a more fundamental issue whether or ...

Multiple sclerosis leads to prominent hippocampal atrophy, which is linked to memory deficits. Indeed, 50% of multiple sclerosis patients suffer memory impairment, with negative consequences for quality of life. There are currently no effective memory treatments for multiple sclerosis either pharmacological or behavioral. Aerobic exercise improves memory and promotes hippocampal neurogenesis in...

Brain entropy (BEN) mapping provides a novel approach to characterize brain temporal dynamics, a key feature of human brain. Using resting state functional magnetic resonance imaging (rsfMRI), reliable and spatially distributed BEN patterns have been identified in normal brain, suggesting a potential use in clinical populations since temporal brain dynamics and entropy may be altered in disease...

BACKGROUND The formation of compulsive pattern of drug use is related to abnormal regional neural activity and functional reorganization in the heroin addicts' brain, but the relationship between heroin-use-induced disrupted local neural activity and its functional organization pattern in resting-state is unknown. METHODOLOGY/PRINCIPAL FINDINGS With fMRI data acquired during resting state fro...

results when the two ms groups were compared together, we found that cr was significantly increased (p value=0.008) and naa/cr was significantly decreased (p value=0.03) in non-enhancing lesions in ppms compared with rrms. there was no significant difference in naa, cho or naa/cho between the two ms subtypes. conclusion mrs is a potential way to differentiate ppms and rrms. objectives we compar...

background: cognitive  impairment  is one of the  most crucial disorders  among  multiple  sclerosis (ms) patients. since  ms  is  an inflammatory disease   and   boswellia papyrifera has anti-inflammatory effects, the influence of b. papyrifera  on  cognitive  impairment   in  ms patients   has been investigated  in the present study. methods: in this clinical trial, 80 ms patients  who referr...