The development of traditional tumor-targeted drug delivery systems based on EPR effect and receptor-mediated endocytosis is very challenging probably because of the biological complexity of tumors as well as the limitations in the design of the functional nano-sized delivery systems. Recently, multistage drug delivery systems (Ms-DDS) triggered by various specific tumor microenvironment stimul...

The problem of portfolio choice is an example of sequential decision making under uncertainty. Investors must consider their attitudes towards risk and reward in face of an unknown future, in order to make complex financial choices. Often, mathematical models of investor preferences and asset return dynamics aid in this process, resulting in a wide range of portfolio choice paradigms, one of wh...

Coordinating due dates of operations throughout all stages of manufacturing and assembly is a problem especially for complex product structures with uncertainties in process times. A recursive procedure is described to estimate distributions of completion times for each operation. Stage due dates are then calculated to meet speci® ed service targets. Compared with plans from existing heuristic ...

Recently, several procedures have been developed to solve the problem of optimal location and sizing for buffer inventories in a serial production system that is subject to random variations in the magnitude or timing of stage failures, repair times, and demands for finished goods. To handle production systems of realistic complexity, we have developed a simplified mathematical model and an eff...

We address the problem of multiuser detection in fast fading multipath environments for DS-CDMA systems. In fast fading scenarios, temporal variations of the channel cause significant performance degradation even with the RAKE receiver. We use a previously introduced Time-Frequency (TF) RAKE receiver based on a canonical formulation of the channel and signals to simultaneously combat fading and...

As systems have grown more complex, the consequences on their reliable behavior have become severe in terms of cost, life, size etc, and the interest in accessing system reliability and the need for improving the reliability of systems have become very important. This paper presents an analytical model for the reliability evaluation of multipath multistage interconnection networks (MINs). In or...