Downlo cer vaccine feasibility would benefit from reducing the number and duration of vaccinations without ishing efficacy. However, the duration of in vivo studies and the huge number of possible variations cination protocols have discouraged their optimization. In this study, we employed an established model of preventive vaccination using HER-2/neu transgenic mice (BALB-neuT) to validate o–d...

A 65-year-old male presented with chronic mechanical back pain and a 6-month history of a discrete, hyperpig-mented reticular rash on his lower back. On further questioning, the patient admitted to daily use of an electric heating pad over the distribution of the rash (Figure 1). The diagnosis was erythema ab igne (EAI). Historically, EAI has been associated with repeated and prolonged exposure...

“[A]n overview of the past suggests that today’s cial Issue of Development and Psychopatholinvestigators are as much determined by history as ogy that would challenge us, as a field, to they are makers of it.” (Cairns, 1983, p. 90) grapple with the past and, simultaneously, look toward the future. This Special Issue repAs we move forward in the new millennium, resents an important opportunity f...

OBJECTIVE Toll like receptors (TLRs) are one of the main components of the innate im- mune system. It has been reported that expression of these receptors are altered in the female reproductive tract (FRT) during menstrual cycle. Here we used a fallopian tube epithelial cell line (OE-E6/E7) to evaluate the effect of two sex hormones in modulating TLR expression. MATERIALS AND METHODS In this ...

Downlo cer vaccine feasibility would benefit from reducing the number and duration of vaccinations without ishing efficacy. However, the duration of in vivo studies and the huge number of possible variations cination protocols have discouraged their optimization. In this study, we employed an established model of preventive vaccination using HER-2/neu transgenic mice (BALB-neuT) to validate o–d...

Downlo cer vaccine feasibility would benefit from reducing the number and duration of vaccinations without ishing efficacy. However, the duration of in vivo studies and the huge number of possible variations cination protocols have discouraged their optimization. In this study, we employed an established model of preventive vaccination using HER-2/neu transgenic mice (BALB-neuT) to validate o–d...

The term "slow infection" was coined originally in the veterinary literature to describe several trans­ missible diseases of sheep. 1 Two of these diseases, scrapie and visna, have become the prototypes of slow infection of the central nervous system (CNS). After inoculation of sheep with tissues from an in­ fected sheep, a latent period of one or more years ensues, during which the sheep appea...

The objective of the study was to assess the effects of diabetic polyneuropathy (DPN) on muscle contractile properties in humans, and how these changes are related to alterations in muscle morphology and denervation. Patients with DPN (n = 12) were compared with age- and sex-matched controls (n = 12). Evoked and voluntary contractile properties, including stimulated twitch responses and maximal...

Antineutrophil cy to plas mic an ti bod ies (ANCA) are a het er o ge neous group of cir cu lat ing an ti bod ies di rected to ward the cy to plas mic con stit u ents of neutrophil gran ules and monocytes. ANCA were first de scribed in 1982 by Davies et al. in a few pa tients with seg men tal necrotizing glomerulone phritis (1,2). The im por tance of this ob ser va tion had not been rec og nized...

Polymorphic structures of the neutrophil Fcgreceptor IIIb gen frequency of 5% in the white population. The same fre(FcgRIIIb) result in alloantibody formation that causes alloquency was found by genotyping, for which a technique immune neonatal neutropenia and transfusion reactions. Albased on polymerase chain reaction (PCR) using sequenceloantigens located on FcgRIIIb include the antigens NA1 ...