Adenovirus vectors (rAd) are widely used in gene therapy to deliver genes of interest. It is therefore essential to develop a purification process that clears the adenovirus of undesired contaminants while purifying high titre stock adenovirus. The current standard method of purification uses a CsCl density gradient, which is formed during centrifugation. The limitations of this procedure inclu...

INTRODUCTION Thyroglosal duct cyst is a common anomaly with an incidence of 7% in adults, the rate of carcinoma in TGDC is 0.7-1.6%, and are extremely rare those originated in the hyoid bone. PRESENTATION OF CASE A 60 years old male patient, had a hard mass in the anterior neck. CT revealed a hyoid tumor. Hyoid bone resection was performed, the pathological report show a conventional papillar...

Flowthrough anion exchange chromatography is commonly used as a polishing step in downstream processing of monoclonal antibodies and other therapeutic proteins to remove process-related impurities and contaminants such as host cell DNA, host cell proteins, endotoxin, and viruses. DNA with a wide range of molecular weight distributions derived from Chinese Hamster Ovary cells was used to advance...