نتایج جستجو برای: mutagen
تعداد نتایج: 1672 فیلتر نتایج به سال:
Therapy-induced cancers are a severe complication of genotoxic therapies. We used heterozygous Nf1 mutant mice as a sensitized genetic background to investigate tumor induction by radiation (RAD) and cyclophosphamide (CY). Mutagen-exposed Nf1(+/-) mice developed secondary cancers that are common in humans, including myeloid malignancies, sarcomas, and breast cancers. RAD cooperated strongly wit...
The reactive metobolite responsible for benzene hematotoxicity and carcinogenicity is unknown. It can be hypothesized that the ultimate carcinogen derived from benzene metabolism might also act as a mutagen. This laboratory has recently developed a new assay that can detect mutagens of all types, using a single strain of bacteria, E. coli WP2s (lambda), as a target. Different genetic end points...
The aim of the present study was to investigate the antigenotoxic properties of the probiotic Lactobacillus rhamnosus IMC501; DNA damage was induced by one representative food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Mice were treated orally with suspensions of lactobacilli for 10 days before administration of food mutagen. During the treatment, the abundance of lactobac...
Mice fed a diet containing 0.3 or 0.03% triethanolamine developed malignant tumors. Females showed a high incidence of tumors in lymphoid tissues, while this type was absent in males. Tumors in other tissues were produced at a considerable rate in both sexes, but no hepatoma was found. Triethanolamine was not mutagenic to Bacillus subtilis by itself, but it became mutagenic after reacting with ...
1. Machado Cda S, Venancio VP, Aissa AF, Hernandes LC, de Mello MB, Del Lama JE, Marzocchi-Machado CM, Bianchi ML, Antunes LM. Vitamin D3 deficiency increases DNA damage and the oxidative burst of neutrophils in a hypertensive rat model. Mutat Res Genet Toxicol Environ Mutagen. 2016 Mar; 798–799: 19–26. doi: 10.1016/j.mrgentox.2016.01.005. CrossRef Google Scholar
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