Lung cancer is a leading cause of death among all the worldwide and it has highest occurrence mortality rates. <em>Mycobacterium</em> <em>tuberculosis</em> (MTB) induced tuberculosis been known as one risk factors for lung carcinogenesis. The exact mechanism MTB understood to date. Several research epidemiological studies about link between exist. It proposed that causes...

Objectives: Cultivation and identification of mycobacteria to species level remains difficult and time-consuming. Hence, easy and rapid diagnostic methods are necessary for the differentiation of Mycobacterium tuberculosis (MTB) from non-tuberculous mycobacteria (NTM). The present study aims to detect and differentiate MTB from NTM isolated from clinical samples by immunochromatographic test (I...

BACKGROUND Depletion of T cells following infection by Mycobacterium tuberculosis (Mtb) impairs disease resolution, and interferes with clinical test performance that relies on cell-mediated immunity. A number of mechanisms contribute to this T cell suppression, such as activation-induced death and trafficking of T cells out of the peripheral circulation and into the diseased lungs. The extent ...

Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a major infectious disease worldwide. Moreover, latent M. tuberculosis infection is more likely to progress to active TB and eventually leads to death when HIV infection is involved. Thus, it is urgent to develop a novel TB vaccine with immunogenicity to both M. tuberculosis and HIV. In this study, four uncharacterized T cell epitop...

Tuberculosis (TB) remains the leading cause of death due to a single pathogen, accounting for 1.5 million deaths annually on global level. Mycobacterium tuberculosis, causative agent TB, is persistently exposed stresses such as reactive oxygen species (ROS), nitrogen (RNS), acidic conditions, starvation, and hypoxic all contributing toward inhibiting bacterial proliferation survival. Iron–sulfu...

Tuberculosis is a major infectious disease that globally causes the highest human mortality. From this aspect, this study was carried out to evaluate novel pharmacological activities/effects of artesunate and artemisinin causing anti-tubercular activity/effects against Mycobacterium tuberculosis (Mtb). The anti-Mtb activities/effects of artesunate and artemisinin were evaluated using different ...

Abstract Tuberculosis (TB) disease remains the leading cause of mortality from an infectious globally, with estimated 1.6 million deaths in 2021. TB is caused by infection Mycobacterium tuberculosis (Mtb), resulting variable outcomes asymptomatic latent to clinical disease. However, most individuals exposed Mtb never develop We hypothesize that host factors, including metabolic pathways, determ...

In this study, we report a new approach that allows dissection of distinct pathways regulating induction of early adaptive immunity in response to Mycobacterium tuberculosis (Mtb). We used traceable murine dendritic cells (DCs) and macrophage populations to chart their migratory pattern in response to Mtb, and found that only DCs receiving inflammatory stimuli from Mtb up-regulated their expres...

Cystic Fibrosis (CF) is a multisystem disease predominantly affecting the airways and predisposing patients to recurrent infections with various multidrug resistant organisms. Mycobacterium tuberculosis (MTB) infection is rarely seen, but considered a potential pathogen in CF patients. We report a 26 year old pregnant CF patient on Ivacaftor who was admitted with symptoms suggestive of tubercul...

Pelvic tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis (MTB) (95%) or Mycobacterium bovis (5%). The incidence of pelvic tuberculosis is difficult to assess as many patients are asymptomatic for 10 to 20 years, therefore the disease often comes to light only incidentally during the course of investigation for a gynecological complaint (such as problems co...