نتایج جستجو برای: myeloid derived suppressor cells
تعداد نتایج: 1797714 فیلتر نتایج به سال:
It is generally accepted that the success of immunotherapy depends on the presence of tumor-specific CD8⁺ cytotoxic T cells and the modulation of the tumor environment. In this study, we validated mRNA encoding soluble factors as a tool to modulate the tumor microenvironment to potentiate infiltration of tumor-specific T cells. Intratumoral delivery of mRNA encoding a fusion protein consisting ...
PGE(2) is the key factor needed for MDSCs development, accumulation and functional stability. PGE(2) initiates an EP2/EP4-mediated positive feedback between COX2 and PGE(2) in monocytic precursors, redirecting dendritic cell differentiation to MDSCs. COX2- or EP2/EP4- blockade abrogates MDSC functions and their CXCR4-CXCL12-mediated attraction to cancer environment, providing convenient immunot...
vascular adhesion protein-1 (vap-1) is an endothelial cell surface-expressed oxidase involved in leukocyte traffic. the adhesive function, and therefore leukocyte infiltration to different tissues, can be blocked by anti-vap-1 antibodies as well as small molecule vap-1 inhibitors. several papers have been published on the effect of vap-1 blockade on both leukocyte accumulation into tumors and n...
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