Background The quest to quantify myocardial perfusion has been largely motivated by the desire to obtain quantitative, observer-independent, and reproducible measures of myocardial perfusion. Spiral pulse sequences have multiple advantages for myocardial perfusion imaging including high acquisition efficiency, high signal to noise (SNR) and robustness to motion. We have developed a spiral pulse...

UNLABELLED In patients with diabetes mellitus, myocardial perfusion defects are often observed in the absence of obstructive epicardial coronary artery disease (CAD), thereby presenting a diagnostic problem. We hypothesized that these perfusion abnormalities may be explained by endothelial dysfunction or occult coronary atherosclerosis. METHODS Prospectively, 130 asymptomatic patients with di...

OBJECTIVE Angina and the presence of myocardial ischaemia are common in hypertrophic cardiomyopathy. Dual chamber pacing results in clinical improvement in these patients. This study evaluates the effects of permanent dual chamber pacing on absolute regional myocardial perfusion and perfusion reserve. SETTING University hospital. PATIENTS AND DESIGN Six patients with hypertrophic cardiomyop...

OBJECTIVE To determine whether the size of a perfusion defect seen at myocardial perfusion MR imaging represents the extent of irreversibly damaged myocardium in acute reperfused myocardial infarction. MATERIALS AND METHODS In nine cats, reperfused myocardial infarction was induced by occlusion of the left anterior descending coronary artery for 90 minutes and subsequent reperfusion for 90 mi...

Myocardial perfusion SPECT imaging with Tc99m-sestamibi is the most accurate non-invasive means of detecting coronary artery disease and assessing the severity of perfusion abnormalities in the patients with coronary stenosis. Though simple and straight forward the results produced by the technique is very much affected by the details being used. One of the main problems with the test, wh...

BACKGROUND Scintigraphic myocardial perfusion imaging is the most widely used noninvasive modality for the detection of coronary artery disease (CAD). A technique for direct imaging of exercise-induced myocardial ischemia is highly desirable and preferable over perfusion imaging but is presently unavailable. We evaluated the feasibility and diagnostic accuracy of direct imaging of exercise-indu...

BACKGROUND Optimal parameters for machine perfusion preservation of hearts prior to transplantation have not been determined. We sought to define regional myocardial perfusion characteristics of a machine perfusion device over a range of conditions in a large animal model. METHODS Dog hearts were connected to a perfusion device (LifeCradle, Organ Transport Systems, Inc, Frisco, TX) and cold p...

The initial myocardial uptake of thallium-201 depends on myocardial blood flow distribution. The phenomenon of delayed thallium redistribution after transiently or chronically altered myocardial perfusion has been described. The net myocardial accumulation of thallium-201 after injection depends upon the net balance between continuing myocardial extraction from low levels of recirculating thall...

Different software tools for quantification of myocardial perfusion SPECT (MPS) studies are routinely used. Several perfusion parameters can be computed automatically. Interpretation of the MPS should start with visual inspection of the rotating planar images, visual analysis of reconstructed SPECT slices and then quantitative analysis to confirm the visual impression. Quantification should be ...