Cell contractility and migration by integrins depends on precise regulation of protein tyrosine kinase and Rho-family GTPase activities in specific spatiotemporal patterns. Here we show that protein tyrosine phosphatase PTP1B cooperates with β3 integrin to activate the Src/FAK signalling pathway which represses RhoAmyosin-dependent contractility. Using PTP1B null (KO) cells and PTP1B reconstitu...

Patients with suspected complications of gallstone disease should be evaluated for alternative diagnoses, as well as complications of gallstones such as pancreatitis and cholangitis. Laboratory evaluation for all these patients should include a complete blood count, basic serum chemistries, liver function tests, serum amylase and lipase, and urinalysis. A urine pregnancy test should always be p...

Hadamard matrices of order n with maximum excess o(n) are constructed for n = 40, 44, 48, 52, 80, 84. The results are: o(40)= 244, o(44)= 280, o(48)= 324, o(52)= 364, o(80)= 704, 0(84) = 756. A table is presented listing the known values of o(n) 0< n ~< 100 and the corresponding Hadamard matrices are constructed. For the remaining values of n = 56, 60, 68, 72, 76, 88, 92, 96 the largest values ...

A long-standing question in the planetary sciences asks what the Earth is made of. For historical reasons, volatile-depleted primitive materials similar to current chondritic meteorites were long considered to provide the `building blocks' of the terrestrial planets. But material from the Earth, Mars, comets and various meteorites have Mg/Si and Al/Si ratios, oxygen-isotope ratios, osmium-isoto...

New diagnostic criteria have been proposed for arrhythmogenic right ventricular cardiomyopathy (ARVC). These “Padua criteria” include late gadolinium enhancement (LGE) on cardiac magnetic resonance the left ventricle (LV) and (RV). Yet, potential of LGE to distinguish ARVC from differential diagnoses remains unknown. Assess value its differentials. We included 130 subjects (57% male, 46±17 year...

Abstract Background Glioblastoma (GBM) is an aggressive type of brain cancer that prevalent and fatal in the elderly. Age not only most common risk factor for but also neurodegenerative diseases, previous studies have indicated excess co-occurrence both diseases. Here, we aim to map Alzheimer (AD)-related pathology GBM-adjacent cortex. Material Methods To this end, screened a cohort 99 individu...

Termites are economically-important structural pests, costing residents of Hawaii over $100 million annually. On Oahu, the last published termite swarming survey occurred from 1969 to 1971, and the last termite hand-collection survey occurred from 1998 to 2000. To contribute data on termite occurrences on Oahu, a light-trap survey took place from February 2011 to September 2012, and a hand-coll...