نتایج جستجو برای: n arylidene 2 2 phenoxyphenyl acetohydrazide derivatives
تعداد نتایج: 3204168 فیلتر نتایج به سال:
In the title compound, C(19)H(17)N(3)O(3)·CH(4)O, the mean planes of the benzene ring and the quinoline rings make a dihedral angle of 75.5 (2)°. The acetohydrazide mol-ecules are connected via pairs of inter-molecular O-H⋯O hydrogen bonds into inversion dimers, and the methanol solvent mol-ecule is linked to the acetohydrazide mol-ecule via inter-molecular N-H⋯O and bifurcated O-H⋯(N,O) hydrog...
A new route to 3-(4-arylmethylamino)butyl-5-arylidene-2-thioxo-1,3-thiazolidine-4-one 9 was developed in six steps from commercial 1,4-diaminobutane 1 as starting material. The key step of this multi-step synthesis involved a solution phase "one-pot two-steps" approach assisted by microwave dielectric from N-(arylmethyl)butane-1,4-diamine hydrochloride 6a-f (as source of the first point diversi...
A simple, efficient and environment-friendly procedure for the synthesis of 5-arylidene rhodanines derivatives via a Knoevenagel type reaction was developed using rhodanine, variety differently substituted aldehydes Na2SO3 as benign catalyst in ethanol. Selected were subjected to basic hydrolysis afford 2-mercapto-3-substituted-acrylic acids. The presence boronic acid group is well tolerated su...
A novel series of oxyiminoacetic acid derivatives were synthesized in an effort to develop a potent antidiabetic agent, which does not contain the 2,4-thiazolidinedione moiety. These compounds were evaluated for glucose and lipid lowering effects in genetically obese and diabetic KKA(y) mice. Several of the compounds showed strong antidiabetic activity, including functional potency at peroxisom...
The hydrazide-hydrazone derivative 1 was formed through the reaction of cyanoacetic acid hydrazide with 2-acetylfuran. Compound 1 underwent a series of hetrocyclization reactions through its reaction with different chemical reagents to produce arylidene, coumarin, aryl hydrazone, pyridine, thiophene and thiazole derivatives 2–10. The MIC values for the newly synthesized products were tested aga...
2-(6,8-Dibromo-2-methylquinazolin-4-yloxy)-acetohydrazide (4) was prepared by the reaction of 6,8-dibromo-2-methylbenzo-[d][1,3]oxazin-4-one with formamide to afford quinazolinone 2, followed by alkylation with ethyl chloroacetate to give the ester 3. Treatment of ester 3 with hydrazine hydrate and benzaldehyde afforded 4 and styryl quinazoline 5. The hydrazide was reacted with triethyl orthofo...
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