نتایج جستجو برای: n disubstituted urea

تعداد نتایج: 1007367  

2014
Kurt S. Van Horn Xiaohua Zhu Trupti Pandharkar Sihyung Yang Brian Vesely Manu Vanaerschot Jean-Claude Dujardin Suman Rijal Dennis E. Kyle Michael Zhuo Wang Karl A. Werbovetz Roman Manetsch

A series of N(2),N(4)-disubstituted quinazoline-2,4-diamines has been synthesized and tested against Leishmania donovani and L. amazonensis intracellular amastigotes. A structure-activity and structure-property relationship study was conducted in part using the Topliss operational scheme to identify new lead compounds. This study led to the identification of quinazolines with EC50 values in the...

Journal: :Chemical Science 2023

Herein, we report the first palladium/MPAA catalyzed enantioselective C-H activation/[4+1] annulation of diarylmethyltriflamide and olefins to construct chiral cis-1,3-disubstituted isoindoline derivatives. The use readily accessible mono N-protected amino acid...

Journal: :Organic letters 2015
Xiang-Wei Du Levi M Stanley

Tandem reactions involving Rh-catalyzed intermolecular hydroacylations of alkynes with salicylaldehydes followed by intramolecular oxo-Michael additions are described for the diastereoselective synthesis of 2,3-disubstituted chroman-4-ones. The tandem hydroacylation/oxo-Michael additions occur to form 2,3-disubstituted chroman-4-ones in high yields from a range of 1,2-disubstituted acetylenes a...

Journal: :The Biochemical journal 1956
H ROSENBERG A H ENNOR J F MORRISON

Arginine has been estimated by precipitation as the picrate and flavianate complexes, enzymically by the action of arginase followed by the estimation of the urea formed, microbiologically and colorimetrically (cf. Block & Boiling, 1947). The colorimetric method developed by Sakaguchi (1925a, b) has been most widely used. This method relies upon the formation of a red-coloured complex produced ...

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