Opiate overdose produces pinpoint pupils and varying degrees of respiratory depression and impairment of consciousness. If there is coma or bradypnoea, the opiate antagonist naloxone should be given intravenously. If the patient has taken a long-acting opioid such as methadone, a naloxone infusion should be considered1. After the administration of naloxone, opiate-dependent patients will experi...

The effect of loperamide and naloxone on mouth-to-caecum transit time was evaluated by the lactulose hydrogen breath test in four men and four women. Each subject underwent tests during the administration of placebo, loperamide (12-16 mg po), naloxone (40 micrograms/kg/h by a three-hour intravenous infusion), and loperamide plus naloxone, carried out at intervals of one or two weeks. The transi...

Take-­‐Home Naloxone to Be Prescribed Primary care clinics will be prescribing take-­‐home naloxone for patients at risk for opioid overdose, this includes patients on long term opioids for pain and those abusing prescription opioids or heroin. Formulations: naloxone can be given by intramuscular (IM) injection or intranasal (IN) administration. Most patients will be prescribed IN naloxone beca...

Maternal and umbilical venous serum naloxone concentrations were measured after the i.v. (30 mothers) or i.m. (seven mothers) injection of naloxone 400 micrograms. Following i.v. naloxone there was rapid transfer to the fetus and therapeutic plasma concentrations could be expected in 1 or 2 min. However, following i.m. administration, neonatal concentrations were variable. In five non-pregnant ...

The nucleus accumbens is a terminal area of the mesolimbic dopaminergic system that arises in the ventral tegmental area. Opioids are thought to enhance dopaminergic activity in the nucleus accumbens by activating δ- and μ-opioid receptors in the ventral tegmental area. However, δ- and μ-opioid receptor agonists increase extracellular levels of accumbal dopamine when infused directly into the n...

The freshwater crab Aegla platensis was used as a model to induce ovarian growth by adding different neuroregulators to a pellet food formulation. Added compounds were the dopaminergic inhibitor spiperone or the enkephalinergic inhibitor naloxone, both of them at a dose of 10(-8) mol/animal. Animals were fed on the enriched pellets twice a week. After 7 wk, the gonadosomatic index (GI) was calc...

PURPOSE To determine whether epidural naloxone preserved analgesia while minimizing side effects caused by epidural morphine. METHODS Eighty patients undergoing combined epidural and general anesthesia for hysterectomy were randomly assigned to one of four groups. All received 2 mg epidural morphine bolus one hour before the end of surgery and a continuous epidural infusion was started contai...

Ninety-nine unselected patients were given a standardized general anaesthetic with fentanyl 1.5 microgram . kg-1 every 30 minutes and were randomly divided into three equal Groups: Group I patients received naloxone 0.1 mg. Group II naloxone 0.2 mg, and Group III naloxone 0.4 mg, at the end of operation and after the reversal of neuromuscular blockade. After administration of naloxone systolic ...

Conflicting reports have appeared in the literature regarding the effect of the opiate antagonist naloxone on ischemic neurologic deficits. We report the results of a study using naloxone in our model of focal cerebral ischemia in the awake primate. A total of 14 adult baboons were subjected to six-hour occlusion of the left middle cerebral artery (MCA). Seven animals served as controls and sev...

In this study, we determined if changes in heart catecholamine content during naloxone-induced withdrawal correlated with modifications in heart rate. In addition, we determined plasma concentrations of corticosterone as an index of the hypothalamo-pituitary-adrenal (HPA) axis. The effects of naloxone on norepinephrine, epinephrine or dopamine content and turnover, plasma concentrations of cort...