Bone repair required for successful arthroplasty can be compromised in patients with comorbid conditions, such as osteoporosis, diabetes mellitus, and chronic kidney disease. Biological compounds have been proposed to promote bone health and repair. The authors have designed a new animal model for testing bone promoting compounds in the in vivo environment. For initial validation of this model,...

Introduction Conclusions References Tables Figures ◭ ◮ ◭ ◮ Back Close Full Screen / Esc Abstract Introduction Conclusions References Tables Figures ◭ ◮ ◭ ◮ Back Close Full Screen / Esc Abstract The concern of adverse health impacts from exposure to vehicle-emitted nanoparticles has been escalating over the past few years. In order to meet more stringent EPA emission standards for particle mass ...

Molecular dynamics (MD) simulations were performed on a model polymer–nanoparticle composite (PNPC) consisting of spherical nanoparticles in a bead-spring polymer melt. The polymer-mediated effective interaction (potential of mean force) between nanoparticles was determined as a function of polymer molecular weight and strength of the polymer–nanoparticle interaction. For all polymer–nanopartic...

Why NaNoparticles? One of the key reasons that nanoparticles have promise in the treatment of cancer is that they can be targeted to tumors through antigen-dependent (specific) or antigen-independent (nonspecific) mechanisms. Specific targeting relies on the interaction of antigens on the surface of nanoparticles with tumor cell receptors. A variety of molecules including peptides (arginine– gl...

We review recent work on DNA-linked gold nanoparticle assemblies. The synthesis, properties, and phase behavior of such DNA-gold nanoparticle assemblies are described. These nanoparticle assemblies have strong optical extinction in the ultraviolet and visible light regions; hence, the technique is used to study the kinetics and phase transitions of DNA-gold nanoparticle assemblies. The melting ...

ABSTRACT A newly arising challenge in the field of nanoparticle research concerns the control and the understanding of the interparticle interactions and interparticle properties. This should allow the development of materials based on nanoparticle assemblies which represents a great opportunity to exploit nanoparticle collective properties. Although some nanoparticle networks have been reporte...

Molecular dynamics simulations were performed to study the ion and water distribution around a spherical charged nanoparticle. A soft nanoparticle model was designed using a set of hydrophobic interaction sites distributed in six concentric spherical layers. In order to simulate the effect of charged functionalyzed groups on the nanoparticle surface, a set of charged sites were distributed in t...

Viral infections can cause of death in humans worldwide, despite the tremendous  progress in human medicine. Particle size is a very important physical characteristic that can affect bioavailability and circulation time of nanoparticles. The ratio of large surface area and volume of nanoparticle enhanced solubility of poorly soluble drug compounds, optimum surface charge of the nanoparticle wi...

Background: Despite the tremendous progress in human medicine, viral infections can cause death in them. Due to the high prevalence of viruses, it is required to develop novel treatment strategies and provide the site-specific delivery of antiviral agents at the viral reservoirs. Objectives: Particle size is a vital physical characteristic that can affect the bioavailability and circulation ti...