Dendrimer-encapsulated Pt nanoparticles can be synthesized by Pt2þ coordination with dendrimers followed by reduction. In the present study, we have systematically investigated the coordination kinetics of PtCl4 2 with fourth-generation hydroxyl-terminated poly(amidoamine) (PAMAM G4-OH) dendrimers using UV vis spectroscopy measurements. Our experimental investigation clarifies that Pt2þ coordin...

To overcome the current limit of tip-enhanced spectroscopy that is based on metallic nano-probes, we developed a new scanning probe with a metallic nanostar, a nanoparticle with sharp spikes. A Au nanoparticle of 5 nm was first attached to the end of a tip through DNA-DNA hybridization and mechanical pick-up. The nanoparticle was converted to a nanostar with a core diameter of ∼70 nm and spike ...

This paper describes an investigation of the uptake of Cu(II) by poly(amidoamine) (PAMAM) dendrimers with an ethylenediamine (EDA) core in aqueous solutions. We use bench scale measurements of proton and metal ion binding to assess the effects of (i) metal ion-dendrimer loading, (ii) dendrimer generation/terminal group chemistry, and (iii) solution pH on the extent of binding of Cu(II) in aqueo...

Dendrimers are a new class of polymeric materials. They are highly branched, monodisperse macromolecules. The structure of these materials has a great impact on their physical and chemical properties. As a result of their unique behaviour dendrimers are suitable for a wide range of biomedical and industrial applications. The paper gives a concise review of dendrimers' physico-chemical propertie...

Large unilamellar liposomes and multilamellar vesicles consisting of DMPC interacted with cationic phosphorus-containing dendrimers CPDs G3 and G4. DSC and ζ -potential measurements have shown that liposomal-dendrimeric molecular recognition occurs due to the interaction between the complementary surface groups. Calorimetric studies indicate that the enthalpy of the transition of the lipids tha...

S ince their introduction in 1985 by Tomalia et al. (1) and Newkome et al. (2), dendrimers have attracted much attention because of their fascinating structure and unique properties (3, 4). Dendrimers are globular, size monodisperse macromolecules in which all bonds emerge radially from a central focal point or core with a regular branching pattern and with repeat units that each contribute a b...

Dendrimers are highly branched macromolecules possessing, in most cases, identical terminal functions. However, it is sometimes desirable to have two types of surface functions order fulfil specific properties. The stochastic functionalization frequently used for such purposes, but the presence an uncontrolled number each type function, albeit acceptable research has no practical use. Thus, fin...

Ketoconazole (KET), an imidazole derivative with well-known antifungal properties, is lipophilic and practically insoluble in water, therefore its clinical use has some practical disadvantages. The aim of the present study was to investigate the influence of PAMAM-NH(2) and PAMAM-OH dendrimers generation 2 and generation 3 on the solubility and antifungal activity of KET and to design and evalu...