Increased mucin expression is a feature of nasal polyposis. Corticosteroids reduce polyp size and symptoms, but their effect on mucin production remains unknown. In this study, the effects of intranasal corticosteroids on MUC5AC mucin expression, nasal resistance, eosinophil and neutrophil infiltration, epidermal growth factor receptor (EGFR), interleukin (IL)-8, and tumour necrosis factor (TNF...

This paper reports the first case of fibroepithelial polyp arising independently of the external auditory canal. A 16-year-old female patient presented to our clinic for aural fullness of the left side. Physical examination revealed a papillomatous tumor at the posterior wall of the inlet of the left external auditory canal. After biopsy, which yielded a diagnosis of benign papilloma, the patie...

Antrochoanal polyp was described by Professor Gustav Killian, in 1906, giving a specificity among polyposis; it represents 4-6% of all nasal polyps and displays both analogies and differences with bilateral nasal polyposis. Antrochoanal polyp is a benign lesion originating from the mucosa of the maxillary sinus, growing through the accessory ostium into the middle meatus and, thereafter, protru...

BACKGROUND The waiting time for functional endoscopic sinus surgery (FESS) in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) in the Canadian public healthcare system can be lengthy. Many such patients have significant nasal obstruction resulting in a poor quality of life. A simple and safe office-based polypectomy device to debulk nasal polyps allows immediate alleviation of...

OBJECTIVE To evaluate the lipopolysaccharide induction of cyclooxygenase-2 (COX-2) in long-term epithelial cultures from nasal polyp tissue of patients with cystic fibrosis (CF) and severe nasal polyposis. DESIGN Experimental and histologic study. SETTING Department of Otorhinolaryngology, University of Ulm, Ulm, Germany. PARTICIPANTS Nasal polyp tissue was evaluated from 9 patients with ...

the Management of Nasal Polyposis? Chronic rhinosinusitis with nasal polyps is a common health problem, affecting 2% to 5% of the general population. Although the condition is not lifethreatening, it is costly in terms of health care expenditures, decreased quality of life, and negative effects on lower airway disease (1–3). European guidelines recommend intranasal corticosteroids as first-line...

Proteasome inhibitors, used in cancer treatment for their proapoptotic effects, have anti-inflammatory and antifibrotic effects on animal models of various inflammatory and fibrotic diseases. Their effects in cells from patients affected by either inflammatory or fibrotic diseases have been poorly investigated. Nasal polyposis is a chronic inflammatory disease of the sinus mucosa characterized ...

Nasal polyp is a benign lesion that arises from the mucosa of the nasal sinuses or from the mucosa of the nasal cavity as a macroscopic edematous mass. The exact etiology is still unknown and controversial, but it is assumed that main causes are inflammatory conditions and allergy. It is more common in allergic patients with asthma. Interleukin-5 has found to be significantly raised in nasal po...

© Copyright The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://e-aair.org Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine expressed in skin, gut, lungs, and thymus. TSLP signals via the TSLP receptor (TSLPR), a heterodimer of the IL-7 receptor α chain and TSLPR chain. The TSLPR chain i...

Nasal polyps are abnormal lesions arising mainly from the nasal mucosa and paranasal sinuses. Since the human class II, major histocompatibility complex, transactivator (CIITA) is a positive regulator of class II, major histocompatibility complex gene transcription, the CIITA gene is thought to be involved in the presence of nasal polyps in asthma...