Many natural phytonutrients have beneficial effects on health [1,2]. In addition, several botanicals have received positive attention, based on their relative safety and the accumulation of evidence of their antiadipogenic and metabolic effects in animals and humans [3]. Natural products can decrease of lipid absorption, energy intake, lipogenesis, pre-adipocyte differentiation and proliferatio...

Background: Adjuvants are used to increase the immunogenicity of new generation vaccines, especially those based on recombinant proteins. Despite immunostimulatory properties, the use of bacterial lipopolysaccharide (LPS) as an adjuvant has been hampered due to its toxicity and pyrogenicity. Brucella abortus LPS is less toxic and has no pyrogenic properties compared to LPS from other gram nega...

Tumors are rarely diagnosed in newborns. Natural history of such tumors, their type, and response to treatment differ from those seen in older children. The etiology is still unclear. In this paper, a retrospective study is presented of diagnostics and management of neonatal tumors from 2008 to 2012. Out of 518 neonatal admissions in that period, tumors were diagnosed in 15 patients (2.8%), in ...

purpose : to evaluate the effectiveness of chemoreduction (crd) for globe saving in patients with intraocular retinoblastoma methods : in this interventional case series all patients with intraocular retinoblastoma were included and classified according to the international classification of retinoblastoma (icrb) from group a to e. six cycles of intravenous vincristine, etoposide and carboplati...

introduction: the activity of hypothalamus-pituitary-adrenal (hpa) axis is increased following inflammation due to its closed relation with immune system. this axis indicates an increased secretion of acth, and corticosterone during acute inflammation while little is known about its activity during chronic inflammation such as rheumatoid arthritis (ra). in this study we measured the products of...

background: naltrexone, an opioid receptor antagonist shifts the immune response toward a th1 profile. in the current study, we evaluated the efficacy of the mixture of ntx and alum, as a new adjuvant, to enhance immune response and induce protection against leishmania major in a mouse model. methods : balb/c mice were immunized three times either autoclaved l. major promastigotes’ antigens alo...

Heat shock proteins (HSP) convey both chaperoned propeptide and danger signal to dendritic cells (DC). However, few studies have compared the two activities. Using a murine inducible hsp70 secreted by cells distinct from those providing the tumor antigens, we showed that hsp70 exerts efficacious adjuvant effects toward DC cross-priming. Hsp70 induces DC maturation and phagocytosis of cellular d...

With the change of dietary habits and lifestyles, people tend to have elevated blood uric acid levels at a younger age, this can cause serious health problems, such as hyperuricemia, gout, cardiovascular diseases nephropathy. However, current clinical acid-lowering drugs mostly side effects. Natural compounds from food other plants properties lowering acid. The objective review is discuss poten...

Natural Killer T (NKT) cells are unique lymphocytes characterized by their expression of a single invariant antigen receptor encoded by Vα14Jα18 in mice and Vα24Jα18 in humans, which recognizes glycolipid antigens in association with the monomorphic CD1d molecule. NKT cells mediate adjuvant activity to activate both CD8T cells to kill MHC-positive tumor cells and NK cells to eliminate MHC-negat...