Background: Ionizing radiation causes deleterious effects on living system mainly due to oxidative damages of macromolecules and protein is the major target due to its abundance. The aim of this study was to investigate the effects of ionizing radiation induced changes in the molecular properties of bovine serum albumin (BSA) its secondary and tertiary structures, degradation, cross linking and...

Background: Synthetic radio-protective agents like aminothiols are toxic and FDA approved agent amifostine is no exception. Some Ayurvedic herbs have shown radioprotective potential. This study was carried out to test and compare the radioprotective potential of Curcuma longa (CL) Tinospora cordifolia (TC), Zizyphus mauritiana (ZM) and Ocimum sanctum (OS) against 2Gy gamma irradiation ...

BACKGROUND Ionizing radiation (IR) initiates intracellular oxidative stress through enhanced formation of reactive oxygen species (ROS) that attack DNA leading to cell death. Because of the diversity of IR applied in medicine, agriculture, industry, and the growing threats of global terrorism, the acquisition of radioprotectors is an urgent need for the nation. However, the applicability of rad...

BACKGROUND Renal cell carcinoma (RCC) is considered resistant to ionizing radiation. Recently, the extracellular matrix (ECM) has been shown to play a role in both drug resistance and radiation resistance (RR). While fibronectin has been extensively investigated in the context of RR, the role of type I collagen [col(I)], a principal constituent of the ECM in tumour metastases, in RR of RCC is u...

14.00 800x600 introduction: oral intake of vitamins which present antioxidant characteristics can protect living organisms against oxidative damage caused by exposure to ionizing radiation. it was previously reported that administration of high levels of vitamin c can lead to increased dna damage through production of hydroxyl radicals from hydrogen peroxide by the fenton reaction. however, our...

G.T. NURMADIYEVA 1, B.A. ZHETPISPAEV 2, D.E. UZBEKOV N.B. SAYAKENOV 3, Zh.U. KOZYKENOVA A.K. KANATBEKOVA S.E. UZBEKOVA A.Sh. KYDYRMOLDINA 4 1. Semey Medical University, Semey, the Republic of Kazakhstan; 2. L.N. Gumilyov Eurasian National Nur-Sultan, 3. Scientific Research Institute Forensic Expertise, […]