Helicobacter pylori (Hp), a Gram-negative bacterial pathogen and aetiologic agent of gastroduodenal disease in humans, is naturally competent for genetic transformation. Natural competence in bacteria is usually correlated with the presence of type IV pili or type IV pilin-like proteins, which are absent in Hp. Instead, we recently identified the comB operon in Hp, carrying four genes tentative...

We present several theoretical contributions which allow Lie groups to be fit to high dimensional datasets. Transformation operators are represented in their eigen-basis, reducing the computational complexity of parameter estimation to that of training a linear transformation model. A transformation specific “blurring” operator is introduced that allows inference to escape local minima via a sm...