Neuroblastoma (NB) is the most common extracranial solid tumor of childhood and is a rapidly growing, highly-vascularized cancer. NBs frequently express angiogenic factors and high tumor angiogenesis has been associated with poor outcomes. Placental growth factor (PlGF) is an angiogenic protein belonging to the vascular endothelial growth factor (VEGF) family and is up-regulated mainly in patho...

Human leukocyte antigen (HLA)-E is highly expressed in a variety of tumors and, in addition to immune escape, may promote tumor growth via other mechanisms. However, the role of HLA-E in neuroblastoma (NB) migration and invasion is unknown. In the present study, HLA-E expression in human NB tumors was measured by immunohistochemistry. The effect of HLA-E on NB cell migration and invasion was st...

This study investigates petrology and major, minor, and rare earth elements ‎geochemistry of ‎East Iranian Eocene–Oligocene volcanic rocks in Sistan suture ‎zone, to examine their ‎petrogenesis and magma evolution. The volcanic rocks include andesite, trachy-andesite, dacite ‎and rhyolite. ‎These calc-alkaline rocks of high-K series are enriched in Large ‎Ion Lithophile ‎Elements of Rb and Ba a...

OBJECTIVE The American College of Rheumatology (ACR) classification criteria for osteoarthritis (OA) permit the categorization of individuals for hand, knee, and hip OA and are of defined sensitivity and specificity. They depend on both clinical and radiographic aspects of OA. The clinical diagnosis of OA in the peripheral skeleton is dependent on the skilled examination of several clinical fea...

Neuroblastoma (NB) is the most common extracranial solid tumor in childhood. One fundamental issue regarding NB recurrence and metastasis is the maintenance of cancer stem cells (CSCs) stemness. Tankyrase 1 (TNKS1) is overexpressed in several types of cancers and in NB cell lines. XAV939 is a small molecule inhibitor of TNKS1 and can induce apoptosis of NB cells. In this study, we showed that t...

We numerically and experimentally investigated the lateral coupling between photonic crystal (PhC) nanobeam (NB) cavities, pursuing high sensitivity and figure of merit (FOM) label-free biosensor. We numerically carried out 3D finite-difference time-domain (3D-FDTD) and the finite element method (FEM) simulations. We showed that when two PhC NB cavities separated by a small gap are evanescently...

PURPOSE Neuroblastoma (NB) is a heterogeneous neoplasm. Detailed biological discrimination is critical for the effective treatment of this disease. Because the tumor behavior of NB is closely associated with the histologic state of differentiation, we thus aimed to identify novel differentiation-associated markers of NB with prognostic implication. EXPERIMENTAL DESIGN A human NB cell line SH-...

ownloade pose: Notch signaling has been implicated to play a critical role in the tumorigenesis of neuroblas(NB) and can modulate calreticulin (CRT) expression that strongly correlates with tumor differenand favorable prognosis of NB. We thus sought to determine how Notch regulates CRT expression ffects NB tumor behavior. erimental Design: The Notch-dependent regulation of CRT expression in cul...

The role of ryanodine receptor (RyR) in cardiac excitation-contraction (E-C) coupling in newborns (NB) is not completely understood. To determine whether RyR functional properties change during development, we evaluated cellular distribution and functionality of sarcoplasmic reticulum (SR) in NB rats. Sarcomeric arrangement of immunostained SR Ca(2+)-ATPase (SERCA2a) and the presence of sizeabl...

Genetic methods for estimating effective population size ( Ne) or the effective number of breeders ( Nb) have become popular, but comparisons of these estimates with demographic estimates of Ne and Nb are rare, especially in anurans. We used three genetic (linkage disequilibrium, temporal moments, Bayesian coalescent-based method) and three demographic models, the latter considering number of b...