The prefrontal cortex is involved in various aspects of working memory like stimulus maintenance and response selection functions. Neurobehavioral studies and neurocomputational models assume a role for NMDA receptors in prefrontal cortex for maintenance processes, while our previous studies on NMDA receptors in the avian prefrontal cortex-analogue, the nidopallium caudolaterale (NCL), showed t...

The neuronal ceroid lipofuscinoses (NCL) are progressive neurodegenerative disorders with onset from infancy to adulthood that are manifested by blindness, seizures, and dementia. In NCL, lysosomes accumulate autofluorescent proteolipid in the brain and other tissues. The mnd/mnd mutant mouse was first characterized as exhibiting adult-onset upper and lower motor neuron degeneration, but closer...

The avian pallial endbrain area nidopallium caudolaterale (NCL) shows important similarities to mammalian prefrontal cortex in connectivity, dopamine neurochemistry, and function. Neuronal processing in NCL has been studied with respect to sensory, cognitive, and reward information, but little is known about its role in more direct control of motor behavior. We investigated NCL activity during ...

NULL Convention Logic (NCL) provides an asynchronous design methodology employing dual-rail signals, quad-rail signals, or other Mutually Exclusive Assertion Groups (MEAGs) to incorporate data and control information into one mixed path. In NCL, the control is inherently present with each datum, so there is no need for worsecase delay analysis and control path delay matching. This dissertation ...

Many sequences in eukaryotic genomes have the potential to adopt a left-handed Z-DNA conformation. We used a previously described assay based on the binding of a mAb to Z-DNA to inquire whether Z-DNA is formed in the rat nucleolin (Ncl) gene in metabolically active, permeabilized nuclei. Using real-time PCR to measure Z-DNA formation, the potential Z-DNA sequence element Z1 [(CA)(10)(CG)(8)] in...

The objective of this study was to screen a dog population from Belgium, the Netherlands and Germany for the presence of mutant alleles associated with hip dysplasia (HD), degenerative myelopathy (DM), exercise-induced collapse (EIC), neuronal ceroid lipofuscinosis 4A (NCL), centronuclear myopathy (HMLR), mucopolysaccharidosis VII (MPS VII), myotonia congenita (MG), gangliosidosis (GM1) and mus...

Neuronal ceroid lipofuscinoses (NCLs; Batten disease) are collectively the most frequent autosomal-recessive neurodegenerative disease of childhood, but the underlying cellular and molecular mechanisms remain unclear. Several lines of evidence have highlighted the important role that non-somatic compartments of neurons (axons and synapses) play in the instigation and progression of NCL pathogen...

Chemical ligation is a popular and rapidly expanding area of research impacting numerous aspects of organic chemistry, biomolecular and materials science. Native chemical ligation (NCL) in particular, has found numerous applications in such areas. This is likely because NCL is a chemoselective coupling reaction between two, normally peptide, components, one bearing a thioester and the other an ...

Abstract Neuronal Ceroid Lipofuscinosis (NCL), also known as Batten disease, is an incurable childhood brain disease. The thirteen forms of NCL are caused by mutations in CLN genes. Mutations one gene, CLN5 , cause variant late-infantile NCL, with age onset between 4 and 7 years. protein ubiquitously expressed the majority tissues studied brain, shows both neuronal glial cell expression. associ...