Introduction: Martian space probe, Viking landers could not measure Ne isotopic ratios, but only had the concentration of Ne as 2.5 ppm (error +3.5, -1.5) in Martian atmosphere [1]. After that, there have been many efforts to determine Ne isotopic composition of Martian atmosphere, by examining the Martian atmospheric gases trapped in impact glasses of the EET 79001 and other shergottites [2-6]...

Repeated administration of large doses of isoproterenol to rats produced myocardial enlargement and a fall in blood pressure. A defect in storage of norepinephrine (NE) was manifested by a decrease in endogenous NE, unimpaired uptake of H-NE, and an accelerated rate of loss of accumulated H-NE. This accelerated loss of H-NE was characterized by a more rapid disappearance of H-NE from the granul...

OBJECTIVE Norepinephrine (NE) induced hypertrophy and remodelling of the extracellular matrix (ECM) in the left ventricle (LV) of the rat heart with resulting fibrosis. However, there was no increased collagen deposition in the right ventricle (RV). To test the hypothesis that lack of RV fibrosis is the result of elevated cleavage of collagens we inhibited the activity of matrix metalloproteina...

Division of f Ne Ne Newb wb wbor or orn n n Me Me M di di dici ci cin ne ne

Division of f Ne Ne Newb wb wbor or orn n n Me Me M di di dici ci cin ne ne

The mammalian nuclear envelope (NE) forms a stable physical barrier between the nucleus and the cytoplasm, normally breaking down only during mitosis. However, spontaneous transient NE rupture in interphase can occur when NE integrity is compromised, such as when the nucleus experiences mechanical stress. For instance, deficiencies in the nuclear lamins and their associated proteins can cause N...

In protracted myocardial ischemia, sympathetic nerve endings undergo ATP depletion, hypoxia and pH(i) reduction. Consequently, norepinephrine (NE) accumulates in the axoplasm, because it is no longer stored in synaptic vesicles, and intraneuronal Na(+) concentration increases, as the Na(+)/H(+) exchanger (NHE) is activated. This forces the reversal of the Na(+)- and Cl(-)-dependent NE transport...

The most prominent afferents impinging upon the noradrenergic neurons of the locus coeruleus (LC) utilize GABA and glutamate. However, peptide neurotransmitters such as galanin, neuropeptide Y, and corticotropin-releasing factor (CRF) have also been localized to LC afferents. The evidence for CRF modulation of LC activity was examined in the present studies. Specifically, the impact of local CR...