Minimally invasive procedures have been increasingly used in the surgical treatment of patients with pancreatic necrosis . They are widely applied abroad as main method and considered a proper alternative to traditional ( open ) interventions for purulent-necrotic parapancreatitis A number methods using minimally surgeries developed , which involved various options drainage formations well subs...

Contributor’s Comment: The liver demonstrates multifocal, coalescing hepatic necrosis. The necrotic hepatocytes are eosinophilic and have indistinct nuclei. Karyorrhectic nuclei are in the necrotic areas. Neutrophils and lymphocytes infiltrate the necrotic regions. Also evident are syncytial cells. Mouse hepatitis virus belongs to the family Coronaviridae and genus Coronavirus. It is a pleomorp...

Clostridium perfringens-induced necrotic enteritis is generally controlled by antibiotics. However, because of increasing antibiotic resistance, other antibacterial agents are required, preferably ones that do not affect the beneficial intestinal microbiota of the host. This study evaluated the in vitro selective growth-inhibitory effect of 8-hydroxyquinoline (8HQ) on C. perfringens vs. bifidob...

Necrosis, a kind of cell death closely associated with pathogenesis and genetic programs, is distinct from apoptosis in both morphology and mechanism. Like apoptotic cells, necrotic cells are swiftly removed from animal bodies to prevent harmful inflammatory and autoimmune responses. In the nematode Caenorhabditis elegans, gain-of-function mutations in certain ion channel subunits result in the...

Antibiotic prophylaxis may be useful in acute necrotising pancreatis, a disease associated with a considerable incidence of infectious complications. The aim of this study was to assess pefloxacin penetration into necrotic pancreatic tissue during human necrotic pancreatitis. Ten patients (mean age 53.2 +/- 17.4 years) with severe acute pancreatitis (mean Ranson score 4.3) were studied. Pefloxa...

Calbindin-D28K has been implicated in the regulation of neuronal cell death. Previously, we demonstrated that calbindin-D28K prevents staurosporine (STS)-induced caspase activation and subsequent apoptosis in a neuronal cell line. However, the role of calbindin-D28K in STS-induced activation of calpain and necrotic cell death was not identified. Staurosporine induced the elevation of intracellu...

BACKGROUND Antiangiogenic treatment may change the tumor microenvironment and hence influence the effect of conventional therapies. The potential of diffusion weighted magnetic resonance imaging (DW-MRI) and dynamic contrast enhanced MRI (DCE-MRI) in assessing microenvironmental effects of sunitinib treatment was investigated in this preclinical study. METHODS Sunitinib-treated and untreated ...