Necrotizing enterocolitis (NEC) is a devastating disease of premature infants, with a mortality rate of 10-50%. It is uncommon in term infants and in premature infants who have not yet been fed. Most commonly NEC develops suddenly in a preterm infant who was otherwise well, with initial symptoms of abdominal distention, bilious or bloody emesis or gastric aspirates, hematochezia, and pneumatosi...

Background: Necrotizing enterocolitis (NEC) is the most common and fatal gastrointestinal disease encountered in Neonatal Intensive Care Unit. Several case reports have shown an association between supraventricular tachycardia necrotizing enterocolitis. This study aimed to determine Methods: was conducted from April 1st, 2016 March 31st, 2022, at Department of Pediatrics, Zhongnan Hospital Wuha...

Acute appendicitis is a common disease in older children, but extremely rare in the neonate. Nevertheless, the true incidence might be underestimated, given the difficulty of the diagnosis. Subtle clinical signs and symptoms usually result in high morbidity and mortality due to delayed diagnosis and surgical intervention. The presentation of neonatal appendicitis can be identical to necrotizing...

Necrotizing enterocolitis (NEC) is a common and often fatal inflammatory disorder affecting preterm infants that develops upon interaction of indigenous bacteria with the premature intestine. We now demonstrate that the developing mouse intestine shows reciprocal patterns of expression of TLR4 and TLR9, the receptor for bacterial DNA (CpG-DNA). Using a novel ultrasound-guided in utero injection...

Objective: The aim of this study is to determine the characteristics radiological manifestations and risk factors in neonates with necrotizing enterocolitis (NEC). Methods: A prospective study over on year starting from January 2008, conducted on 55 neonates with suspected NEC admitted at Children Hospital, Cairo University. Serial X-ray for all neonates were done and assessed Results: 31 (56.4...

Introduction Despite many years of clinical observation and experimental investigation, the pathogenesis of neonatal enterocolitis (NEC) remains elusive. The multifactorial theory suggests that four key risk factors—prematurity, formula feeding, intestinal ischemia, and bacterial colonization—are important prerequisites to the initiation of intestinal injury in neonates (Figure). Current hypoth...

Over a 4 year period, nine of 180 (5%) infants weighing less than 2000 G,admitted to the Aga Khan University Hospital (AKUH) developed necrotizing enterocolitis (NEC). An outbreak of NEC occurred in 1989, during which six infants developed the clinical illness. Overall incidence was 1.1%. Thirty-one birth weight and gestation matched controls were selected for comparison. Risk factors usually c...

Högberg, N. 2013. Experimental and Clinical Necrotizing Enterocolitis. Acta Universitatis Upsaliensis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 898. 47 pp. Uppsala. ISBN 978-91-554-8655-6. Necrotizing enterocolitis (NEC), a severe inflammatory disorder of the gastrointestinal tract with high morbidity and mortality, affects primarily preterm infants....

We report a successful closure of large patent ductus arteriosus (PDA) in low-birth weight preterm neonate using an ADO IIdevice for the first time AFIC/NIHD Rawalpindi. A hemodynamically significant PDA carries anincreased risk morbidity, including chronic lung disease, necrotizing enterocolitis and renal impairment. After failure ofmedical therapy, successful, timely safe transcatheter approp...

Congenital hyperinsulinism (HI) is the most common cause of persistent hypoglycemia in infants and children. In cases of diazoxide-unresponsive HI, alternative medical and surgical approaches may be required to reduce the risk of hypoglycemia. Octreotide, a somatostatin analog, often has a role in the management of these children, but a dose-dependent reduction in splanchnic blood flow is a rec...