Purpose To report a young patient who initially manifested with bilateral anterior nodular scleritis and subsequently developed ocular features typical of Vogt-Koyanagi-Harada (VKH) disease. Case description A 9-year-old girl was diagnosed with bilateral anterior nodular scleritis, which improved with topical administration of corticosteroids and systemic nonsteroidal anti-infl ammatory drugs. ...

Scleritis commonly is a recurrent disease that requires long term immunosuppressive treatment that can be associated with significant adverse effects. Although topical and periorbital steroids are accepted therapeutic options for treatment of scleritis, subconjunctival administration of depot corticosteroids has been considered unsafe owing to the risk of scleral thinning and perforation. Recen...

Infection is a very important but rare cause of scleritis, occurring in about 5%-10% of all patients presenting with scleral inflammation. However, due to the similarity of its presentation, infectious scleritis is often initially managed as autoimmune, potentially further worsening its outcome. The overall visual outcome in infectious scleritis is generally worse than its autoimmune counterpar...

Background Inflammatory ocular pathology (IOP) includes internal and external involvement. IOP may be severe conditions refractory to conventional immunosuppressants even biological therapy. Janus Kinase inhibitors (JAKINIB) had shown efficacy in cases of different immune-mediated inflammatory diseases (IMID). Objectives In patients with treated JAKINIB our aims were a ) assess the Spanish refe...

BACKGROUND Adult-onset Still's disease is a systemic inflammatory disease which presents with uveitis and scleritis in the eye. Intravitreal dexamethasone implants are used for the treatment of refractory uveitis. CASE PRESENTATION A 19-year-old woman diagnosed to have adult-onset Still's disease for fevers, joint pain, and a salmon-colored bumpy rash presented with scleritis and uveitis in t...

Posterior scleritis is a rare underdiagnosed condition that can potentially cause blindness. Its varied presentations lead to delayed or incorrect treatment. We present here the cases of two patients with nodular posterior scleritis mimicking a choroidal metastasis. Two female patients presented with a sudden unilateral visual loss associated with ocular pain. Fundus examination revealed tempor...

This report describes a unique case of coexisting necrobiotic xanthogranuloma and chronic lymphocytic leukemia in a patient presenting with scleritis and uveitis. A 53-year-old Caucasian man diagnosed with anterior uveitis and scleritis for the prior year was referred to our uveitis clinic for further evaluation. Prior uveitis/scleritis workup performed by the referring ophthalmologist was nega...

Purpose To report on a case of uveitis and scleritis resulting as an immune-mediated side effect of cancer immunotherapy with nivolumab and cabiralizumab. Observations Bilateral anterior nongranulomatous anterior uveitis and bilateral diffuse anterior and posterior scleritis occurred following the use of combination cancer immunotherapy. The uveitis and scleritis resolved following temporary ...