The significance Minimum Inhibitory Concentration (MIC) of determination for Meningococci is described and according to the present study a shift in the sensitivity of Meningococcus is occurring, local isolates show higher Minimum Inhibitory Concentration for Chloramphenicol and Azactam. Strains of Meningococcus can successfully be stored in a domestic freezer.

regions of the promoter. variation in the spacing between the-10 and-35 protein in Neisseria meningitidis is caused by Variable expression of class 1 outer membrane

Comparative genome hybridization using the pan-Neisseria microarray identified genes from the gonococcal genetic island (GGI) within Neisseria meningitidis strains of serogroups W-135, H, and Z. While some of these strains contain nearly all of the genes of the GGI, there are differences in the presence of some of these genes between the strains, including between those of the same serogroup. A...

The BamA protein is the key component of the Bam complex, the assembly machinery for outer membrane proteins (OMP) in gram-negative bacteria. We previously demonstrated that BamA recognizes its OMP substrates in a species-specific manner in vitro. In this work, we further studied species specificity in vivo by testing the functioning of BamA homologs of the proteobacteria Neisseria meningitidis...

1. Workowski KA, Berman S. Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep. (Corrected in MMWR Recomm Rep. 2011 Jan 14;60:18 [Note: dosage error in article text]). 2010;59(RR-12):1–110. 2. Takahashi H, Kuroki T, Watanabe Y, Tanaka H, Inouye H, Yamai S, et al. Characterization of Neisseria meningitidis isolates collected from 1974 to 2003 in Japan by multilocus sequence...

Whole-genome sequencing of bacteria and advances in bioinformatics have revolutionized the vaccinology field, leading to the identification of potential vaccine candidates without the need for cultivating the pathogen. This approach, termed "reverse vaccinology", reduces the time and cost required for the identification of candidate vaccines and provides new solutions for those diseases for whi...

We read with interest the report by Cunningham and colleagues (1) regarding the inability of matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDITOF MS) to differentiate Neisseria meningitidis from Neisseria polysaccharea. As highlighted in the article, these two neisseriae are also difficult to distinguish by biochemical methods. Key reactions that might be used ...

Meningococcal disease has historically been associated with military populations, particularly during periods of mobilization. Although the U.S. military has now been engaged in conflicts for nearly a decade, the incidence of meningococcal disease in the U.S. population as a whole has reached historic lows. Despite vaccination of all service members in basic military training, the risk of menin...