One-third of the annual 4 million neonatal deaths occurring worldwide are associated with infections [1,2]. In countries with high neonatal mortality (>45 per 1000 births), 50% of these deaths are attributed to infections [2]. India contributes to one-fifth of the total live births and 27% of global newborn mortality [3]. Essential maternal and newborn care interventions such as clean delivery,...

The human infant is delivered at a stage in which every organ system is very much in the process of rapid development. As such, this stage of life is unique relative to any other that the organism will subsequently experience. This Research Topic focuses on the immune system of the newborn as one such organ system. The articles herein are original research or review articles that discuss some a...

We investigated the prevalence of neonatal deaths in the special care baby unit (SCBU) at the main children's hospital in Tripoli and the factors associated with these deaths. We reviewed the medical records of all neonates who died in our SCBU from 1 January 2003 to 31 December 2005. A total of 1176 neonates were admitted to our SCBU (59.6% males and 40.4% females). Of these, 260 (22.1%) died:...

INTRODUCTION The characteristics of Group B Streptococcal (GBS) early onset (EOD) and late onset (LOD) neonatal infections in Italy were analyzed. Two periods were considered, a first 3-years period (2007-2010), when notification of GBS infections was enforced under the auspices of the Italian Ministry of Health, and a second 1 year period (2012) when reporting on neonatal GBS disease continued...

INTRODUCTION Neonatal infection is an important cause of morbidity and mortality. Neonatal infection surveillance networks are necessary for defining the epidemiology of infections and monitoring changes over time. DESIGN Prospective multicentre surveillance using a web-based database. SETTING 12 English neonatal units. PARTICIPANTS Newborns admitted in 2006-2008, with positive blood, cer...

The study examines production of proinflammatory IL-1b, IL-8, γ -IFN and anti-inflammatory (IL-4) cytokines in newborns from mothers with healthy pregnancy and with the intrauterine infections. Under supervision there were 55 children, newborn from the mothers with herpes virus infections: from them 21 in the early neonatal period, 19 in the late neonatal period. The control group included 15 h...

OBJECTIVE The aim of this study was to compare two different empiric treatments for late-onset neonatal sepsis, vancomycin and oxacillin, in a neonatal intensive care unit with a high prevalence of coagulase-negative Staphylococcus. METHODS A cross-sectional study was conducted in an neonatal intensive care unit from 2011 to 2014. Data from the medical records of at-risk newborns were collect...

objectives the current study aimed to determine the incidence of neonatal infection (nicus) in south sinai neonatal intensive care units, egypt. methods the study included 1023 neonates admitted to neonatal intensive care units in the south sinai state hospitals from january 2010 to september 2014 and scanned for demographic data and the potential risk factors for neonatal septicemia. results t...

Sepsis-related morbidity and mortality are increasing concerns in all Neonatal Intensive Care Units, with reported incidences that are dramatically high regardless of the improvements in the quality of neonatal assistance. Preterm neonates display clinical characteristics that make them prone to infections. Neonatal sepsis is one of the major causes of neonatal death in developing countries. Di...

Neonatal purpura fulminans is a rare and life threatening disease that can be inherited or acquired in etiology. It manifests as DIC and extensive subcutaneous thrombosis. The condition is often fatal unless there is prompt diagnosis, and judicious therapy. The most important causes of this condition are infections and congenital deficiency of anticoagulant proteins C and S.In the case of PC (p...