Numerous genes expressed by intestinal epithelial cells are developmentally regulated, and the influence that adaptive (AI) and passive (PI) immunity have in controlling their expression has not been evaluated. In this study, we tested the hypothesis that both PI and AI influenced enterocyte gene expression by developing a breeding scheme that used T and B cell-deficient recombination-activatin...

Athymic H-2b nude mice received grafts from C57BL/6 (Sendai virus and H-Y antigen cytotoxic T lymphocyte [CTL] responder type), bm1 (H-2Kb mutant, Sendai CTL nonresponder type), or bm12 (H-21-A mutant, H-Y CTL nonresponder type) neonates. In observations of the CTL response to H-Y, both recipients and thymus donors were female. All types of thymus engraftment resulted in mature H-2b splenic T l...

background and objective: there has been a resurgence of nutritional rickets in children in many developing countries. furthermore, vitamin d deficiency is one of the major health problems and unexpectedly has a high prevalence in sunny countries (e.g. middle east). in order to find out the association between vitamin d deficiencies in mothers and their neonates, we designed this study. methods...

vitamin d is important for the development, growth, and mineralization of the skeletal in neonates and children. vitamin d is essential for intestinal absorption of calcium. vitamin d is metabolized to 25-hydroxyvitamin d and then to 1,25-dihydroxyvitamin d. pregnant women in developed countries often have insufficient serum concentrations of 25-hydroxyvitamin d and a supplementation of vitamin...

introduction:  inadequate intake of breast milk in the first days of life leads to weight loss in neonates. jaundice is also more prominent in these infants. in this cross-sectional study, we tried to evaluate the extent of weight loss in term breastfed infants who were hospitalized for idiopathic hyperbilirubinemia. methods: this prospective study involved 1072 infants >48 hours old, who were ...

conclusions in the present study, we identified a key gene rps16 and a significant module involved in ribosome biogenesis in eukaryotes that were related to neonatal sepsis, which might be potential biomarkers for early detection and therapy for neonatal sepsis. background the exact interacting factor that response to the infection for neonatal sepsis is still needed to urgently to be disclosed...

background: determining the prevalence and risk factors of thrombocytopenia among neonates enables us to prevent the inevitable and sometimes irreversible complications. in this study we aimed to survey the frequency of thrombocytopenia and its demographic features and risk factors. materials and methods: in this cross sectional study the platelet counts of 364 neonates admitted to neonatal int...

Rhabdomyoma is a well characterised entity in a neonate. Herein, we report a massive biventricular rhabdomyoma in a neonate presenting with cyanosis and congestive heart failure which was confirmed on autopsy. The report is for documentation of an unusually large tumour.

background: choriocarcinoma is a rare highly malignant trophoblastic neoplasm. it can be preceded by any form of gestation including a complete or a partial mole, miscarriage and normal pregnancy. simultaneous intraplacental choriocarcinoma involving both mother and infant is extremely rare. hepatomegaly, anemia, elevated ßhcg is the diagnostic triad. here we report a 6 weeks old afghan girl in...