All patients with chronic kidney disease (CKD) require treatment to reduce the risk of cardiovascular events and prevent progression renal failure. ACE inhibitors angiotensin receptor blockers are widely used for cardio- nephroprotection in CKD. Sodium glucose cotransporter type 2 (SGLT-2) show significant prospects reducing morbidity mortality this population. SGLT-2 have been developed diabet...

Pleurotus eous is an edible oyster mushroom currently available in Southern part of India. There is no information about the antioxidant and therapeutic properties of this mushroom. Pleurotus eous aqueous extract (PEAE) were prepared and analysed for their antioxidant activity by in vitro assays such as DPPH, hydroxyl radicals, Ferric Thiocyanate (FTC) and Thiobarbituric acid (TBA) test. The ne...

Thymelaea microphylla Coss. et Dur (T. microphylla), a medicinal herb that grows in arid and desert pastures, has been traditionally utilized by Moroccans to treat many diseases, including kidney failure. This study aims evaluate the nephroprotective effect against gentamicin-induced nephrotoxicity (GM), thus antioxidant activity of an aqueous extract rich flavonoids from aerial part T. (APTM)....

Polyaspartic acid (PAA) ameliorates experimental gentamicin nephrotoxicity despite marked accumulation of gentamicin in the renal cortex. The experiments described here probe the extent of PAA's nephroprotective action when increasing doses of gentamicin, in excess of an established nephrotoxic dose (40 mg/kg of body weight per day), are administered. After 10 days, virtually complete nephropro...

Herbal medicines are being used with greater frequency by practitioners of natural medicine in the United States. Many categories of herbs are used, primarily angiotensin antagonists, nonspecific nephroprotective, and immunomodulating/adaptogenic herbs. The most common herbs in each category are discussed both from a historical and scientific perspective. For the first time, a case series of th...

Cissampelos pareira Linn. (Menispermaceae) widely distributed all over India and it is widely used for various kidney disorders. According to the Ayurveda, the kidneys are made up of the "Rakta" and "Meda" dhatus. Treating these two dhatus is also an effective way to treat the kidneys. The plant Cissampelos pareira Linn. is used to treat these two dhatus. This promotes us to undertake a study t...

Production of adrenomedullin (ADM), a vasodilator peptide, increases in response to ischemia and hypoxia in the vascular wall and the kidney. This may be an adaptive response providing protection against organ damage. We investigated the hypothesis that ADM has a nephroprotective effect in two prospective cohorts of patients with type 2 diabetes recruited in France. The highest tertile of plasm...

BACKGROUND/AIMS Leaves of Echinodorus macrophyllus (EM), from the Alismataceae family, have been used in Brazilian folk medicine for their anti-inflammatory and diuretic properties. In this work, the diuretic and nephroprotective activities of crude extracts of EM were evaluated. METHODS Normal Wistar rats were given 0.9% NaCl containing either EM (10-300 mg/kg), furosemide (13 mg/kg) or argi...