Evidence for the important role of the potent oxidant peroxynitrite in peripheral diabetic neuropathy and neuropathic pain is emerging. This study evaluated the contribution of neuronal nitric oxide synthase (nNOS) to diabetes-induced nitrosative stress in peripheral nerve and dorsal root ganglia, and peripheral nerve dysfunction and degeneration. Control and nNOS-/- mice were made diabetic wit...

Twenty lead-exposed men were selected on the basis of a maximum level of lead in the blood of 70-140 ,tg/l00 ml within the past year. There was no clinical evidence of neuropathy attributable to lead and haemoglobin levels were normal. In individuals, maximum motor and sensory conduction and the amplitude of the evoked potentials were normal or borderline in the median, peroneal and sural nerve...

The effect of rapid as well as sustained compressive forces applied to the surface of intact and severed peroneal nerves of rabbits was studied. Considerable effort was taken to ensure a quantitative and consistent experimental paradigm. Stimuli were delivered to the sciatic nerve, and the compound action potential was recorded in the peroneal nerve, with compressive forces applied more proxima...

introduction: high frequency alternating currents is a safe, reversible and selective method for nerve conduction block that has been under study during the last decade as a treatment for the diseases involving abnormal neural impulses. however, reducing the stimulus amplitude, and the undesired onset response, as well as optimizing the stimulus parameters for more effective block is still unde...

IT MAY BE CONCLUDED FROM THE RESULTS OBTAINED IN THESE EXPERIMENTS : 1. That stimulation of the right vagus nerve in the dog usually causes arrest of all the chambers of the heart. 2. That stimulation of the left vagus nerve exerts a moderate negative chronotropic effect on the auricles. 3. That stimulation of the left vagus nerve has a profound effect on the conduction of impulses over the aur...

The authors present a technique to perform nerve conduction study in armadillos (D. novemcinctus) and suggest that 66.17 m/s could be the mean normal nerve conduction velocity for the sciatic nerve, a parameter that could be used for assessment of the peripheral nervous system in this animal, considered the choice for experimental development of leprosy neuropathy and even in other peripheral n...

Median and ulnar nerves were evaluated using established nerve conduction techniques in a control population and in a population of patients with neuropathy. Motor and sensory residual latencies were obtained. The main contributor to the latencies was slowing of the nerve conduction in the smaller attenuated nerve fibres of the hand and fingers.

Hopf's technique was used to measure motor nerve conduction velocity of fibres in the deep peroneal nerve in clinical conditions where damage to the peripheral nervous system was probable. A particular distribution of motor nerve fibre conduction velocity was shown by the analysis of the findings in some of the groups investigated, illustrating the advantages of this method as compared with rou...