Among the synthetic polymers, poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microbial polyester is one of the biocompatible and biodegradable copolymers in the nanomedicine scope. PHBV has key points and suitable properties to support cellular adhesion, proliferation and differentiation of nanofibers. Nanofibers are noticeably employed in order to enhance the performance of biomaterials,...

Currently the clinical standard of care for treatment of extensive peripheral nerve damage is the autograft, which consists of a donor nerve from the patient implanted to bridge the site of injury. This technique, although providing a non-immunogenic solution to guide in nerve regeneration, is limited by several constraints including donor site morbidity. To address these concerns, our lab has ...

Spinal cord injury elicits an inflammatory response that recruits macrophages to the injured spinal cord. Quantitative real-time PCR results have shown that a repair strategy combining peripheral nerve grafts with acidic fibroblast growth factor (aFGF) induced higher interleukin-4 (IL-4), IL-10, and IL-13 levels in the graft areas of rat spinal cords compared with transected spinal cords at 10 ...

background peripheral nerve repair is often complicated by fibroblastic scar formation, nerve dysfunction, and traumatic neuroma formation. use of silicone may improve outcomes of these repairs. in this study, we tried to evaluate effectiveness of silicone gel on rats’ sciatic nerve repair, axon regeneration and scar formation around and in the nervous tissues. methods this experimental study w...

IMPORTANCE Facial nerve injury leads to severe functional and aesthetic deficits. The transgenic Thy1-GFP rat is a new model for facial nerve injury and reconstruction research that will help improve clinical outcomes through translational facial nerve injury research. OBJECTIVE To determine whether serial in vivo imaging of nerve regeneration in the transgenic rat model is possible, facial n...

AIMS The combined treatment of peripheral nerve (PN) graft and fibroblast growth factor (FGF)-1 for spinal cord injury produces functional recovery, but how it affects injury events is still unknown. This project studied the effect of PN graft and FGF-1 on white matter degeneration following spinal cord injury. METHODS Rats were divided into four groups: (i) complete spinal cord transection a...

Despite extensive research and surgical innovation, the treatment of peripheral nerve injuries remains a complex issue, particularly in nonsharp lesions. The aim of this study was to assess the clinical outcome in a group of 16 patients who underwent, in emergency, a primary repair for crush injury of sensory and mixed nerves of the upper limb with biological tubulization, namely, the muscle-ve...

The aim of the present study was to investigate the feasibility of reconstructing the severed pelvic autonomic nerve using an artificial nerve graft after rectal cancer surgery. In this study, Laparotomy was performed in Beagle dogs and nerves of 1 cm long were cut from the hypogastric nerve. Then Fifteen Beagle dogs with 30 hypogastric nerves were randomly assigned to five groups, Group A: ner...